B3GNT2

From Wikipedia, the free encyclopedia

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

Identifiers

B3GNT2; B3GN-T1; B3GN-T2; B3GNT; B3GNT-2; B3GNT1; BETA3GNT

External IDs

OMIM: 605581 MGI: 1889505 HomoloGene: 4797

Gene ontology
Molecular Function:	• galactosyltransferase activity • UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity • transferase activity, transferring glycosyl groups • manganese ion binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• protein amino acid glycosylation • axon guidance • sensory perception of smell • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006577 (mRNA)
NP_006568 (protein)

NM_016888 (mRNA)
NP_058584 (protein)

Location

Chr 2: 62.28 - 62.31 Mb

Chr 11: 22.73 - 22.76 Mb

Pubmed search

[1]

[2]

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2, also known as B3GNT2, is a human gene.^[1]

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains.^[1]

[edit] References

^ ^a ^b Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2.

[edit] Further reading

Amado M, Almeida R, Schwientek T, Clausen H (2000). "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.". Biochim. Biophys. Acta 1473 (1): 35–53. PMID 10580128.
Zhou D, Dinter A, Gutiérrez Gallego R, et al. (1999). "A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases.". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 406–11. PMID 9892646.
Shiraishi N, Natsume A, Togayachi A, et al. (2001). "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.". J. Biol. Chem. 276 (5): 3498–507. doi:10.1074/jbc.M004800200. PMID 11042166.
Ju T, Cummings RD (2003). "A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16613–8. doi:10.1073/pnas.262438199. PMID 12464682.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Isshiki S, Kudo T, Nishihara S, et al. (2003). "Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins.". J. Biol. Chem. 278 (38): 36611–20. doi:10.1074/jbc.M302681200. PMID 12855703.
Hayashi N, Nakamori S, Okami J, et al. (2004). "Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue.". Pathobiology 71 (1): 26–34. doi:10.1159/000072959. PMID 14555842.
Mare L, Trinchera M (2004). "Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans.". Eur. J. Biochem. 271 (1): 186–94. PMID 14686931.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zheng H, Li Y, Ji C, et al. (2005). "Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase.". Mol. Biol. Rep. 31 (3): 171–5. PMID 15560372.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.