B3GAT2

From Wikipedia, the free encyclopedia

Beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)

PDB rendering based on 2d0j.

Available structures: 2d0j

Identifiers

Symbol(s)

B3GAT2; GLCATS; GlcAT-S; KIAA1963; MGC138535

External IDs

OMIM: 607497 MGI: 2389490 HomoloGene: 50574

Gene ontology
Molecular Function:	• galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity • transferase activity, transferring glycosyl groups • manganese ion binding • metal ion binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• carbohydrate biosynthetic process

Orthologs

Human

Mouse

Refseq

NM_080742 (mRNA)
NP_542780 (protein)

XM_981748 (mRNA)
XP_986842 (protein)

Location

Chr 6: 71.62 - 71.72 Mb

Chr 1: 23.72 - 23.8 Mb

Pubmed search

[1]

[2]

Beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S), also known as B3GAT2, is a human gene.^[1]

The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system.^[1]

[edit] References

^ ^a ^b Entrez Gene: B3GAT2 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S).

[edit] Further reading

Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.". DNA Res. 8 (6): 319–27. PMID 11853319.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Marcos I, Galán JJ, Borrego S, Antiñolo G (2003). "Cloning, characterization, and chromosome mapping of the human GlcAT-S gene.". J. Hum. Genet. 47 (12): 677–80. doi:10.1007/s100380200103. PMID 12522689.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kakuda S, Oka S, Kawasaki T (2004). "Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in Escherichia coli.". Protein Expr. Purif. 35 (1): 111–9. doi:10.1016/j.pep.2003.12.021. PMID 15039073.
Kakuda S, Sato Y, Tonoyama Y, et al. (2005). "Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate.". Glycobiology 15 (2): 203–10. doi:10.1093/glycob/cwi001. PMID 15470230.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Shiba T, Kakuda S, Ishiguro M, et al. (2006). "Crystal structure of GlcAT-S, a human glucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope.". Proteins 65 (2): 499–508. doi:10.1002/prot.21118. PMID 16897771.