AZIN1

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Antizyme inhibitor 1
Identifiers
Symbol(s) AZIN1; MGC3832; MGC691; OAZI; OAZIN; ODC1L
External IDs OMIM: 607909 MGI: 1859169 HomoloGene: 22933
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51582 54375
Ensembl ENSG00000155096 ENSMUSG00000037458
Uniprot O14977 O35484
Refseq NM_015878 (mRNA)
NP_056962 (protein)		 NM_018745 (mRNA)
NP_061215 (protein)
Location Chr 8: 103.91 - 103.95 Mb Chr 15: 38.43 - 38.46 Mb
Pubmed search [1] [2]

Antizyme inhibitor 1, also known as AZIN1, is a human gene.[1]

Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: AZIN1 antizyme inhibitor 1.

[edit] Further reading

  • Murakami Y, Matsufuji S, Hayashi S, et al. (2000). "Degradation of ornithine decarboxylase by the 26S proteasome.". Biochem. Biophys. Res. Commun. 267 (1): 1–6. doi:10.1006/bbrc.1999.1706. PMID 10623564. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Koguchi K, Kobayashi S, Hayashi T, et al. (1997). "Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor.". Biochim. Biophys. Acta 1353 (3): 209–16. PMID 9349715. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. PMID 12878157. 
  • Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.". Exp. Cell Res. 289 (2): 211–21. PMID 14499622. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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