Talk:Autoimmune disease

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Removed passage:

some people view them as instances of diseases of affluence.
Who specifically an on what grounds ? Any references ?


____ Here are some references:

[1]

[2]

[3]

These are from a range of sources. Obesity is seen as contributing to diabetes and arthritis. Also the mechanisms of autoimune diseaeses is not well understood, whereas communicable diseases are.

For all of these reasons, I think it is reasonable to say that there are some who view auto immune diseases as examples of diseases of affluence. However, neither type is well understood. Maybe we need a new division of development medicine?

I would appreciate further views on this.

TonyClarke 01:28, 2 Jan 2005 (UTC)

____

Two points: 1. autoimmune diseases are on the rise. (Maybe because people are being cured of other stuff, and maybe just better diagnostics AMONG THE AFFLUENT) 2. Autoimmune diseases are more common under more "hygenic" conditions, ie too clean. Somehow, not being exposed to some agent in nature leads the immune system to react to self. (Sorry that's not coherent.) This was told to me by an autoimmune specialist; I'm sure I;ll find a reference if I get around to looking for it. 67.124.100.215 04:16, 9 May 2005 (UTC)

Well, that sorta ties in with allergy and the hygiene thingie. See Allergy#The hygiene hypothesis. Alex.tan 10:49, 9 May 2005 (UTC)

Hey, good point. Anyway, here's a reference to hygiene hypothesis and MS, with further references. http://scienceweek.com/2005/sw050401-4.htm GangofOne 00:35, 30 May 2005 (UTC)

Just in case anyone ever reads this Talk page: Obesity contributes to Type 2 (non-immune-mediated) diabetes and osteoarthritis. "Worn-out pancreas from eating more than you need" and "worn-out joints from carrying all that weight" are not generally considered autoimmune diseases. 70.137.153.32 23:33, 19 October 2007 (UTC)


Contents

[edit] Proposal: Redirecting content to Autoimmunity

I'm going to bring this up for discussion here, and in the Talk:Autoimmunity page before setting to it. It's occurred to me that there's no discussion of the epidemiology of autoimmunity on that page, and that the discussion of it here actually works much better over there. So barring substantive objection, and rather than duplicate content, I'm going to relocate pretty much the entire introductory text from this article to the main Autoimmunity article. All in favor? Opposed? Jbarin 08:00, 8 May 2007 (UTC)

[edit] I sure from an autoimmune disease called Polymyositis

I sure frokm an autoimmune disease called polymyositis. I do not see it here in thw autoimmune disease listings.

The Muscular Dsytrphy Assosication has it listed on there webite with a very good explanation of it as well.


[edit] Adding a bit more information?

Does anyone mind if we expand the table of accepted autoimmune conditions to include the type of immune reaction, where known? I envision something that looks like this:

Name MeSH? ICD-10 Type Description
Ankylosing spondylitis yes M08.1, M45. B cell is a chronic, painful, progressive inflammatory arthritis primarily affecting spine and sacroiliac joints, causing eventual fusion of the spine.
Aplastic anemia no D60 T8 cell is often caused by an autoimmune attack on the bone marrow.
Celiac disease no K90.0 T8 cell, with antibody component is a disease characterized by chronic inflammation of the proximal portion of the small intestine caused by exposure to certain dietary gluten proteins.
Crohn's disease no K50 T cell is a form of inflammatory bowel disease characterized by chronic inflammation of the intestinal tract. Major symptoms include abdominal pain and diarrhea. There is also a theory that Crohn's Disease is an infectious disease caused by Mycobacterium avium paratuberculosis.
Goodpasture's syndrome yes M31.0 B cell is a disease characterised by rapid destruction of the kidneys and haemorrhaging of the lungs through autoimmune reaction against an antigen found in both organs.
Graves' disease yes E05.0 B cell is the most common form of hyperthyroidism, and is caused by anti-thyroid antibodies that have the effect of stimulating (agonist) the thyroid into overproduction of thyroid hormone.

and so forth. Knowing something about the part of the immune system involved has implications for treatment. (For example, B cell diseases should be treatable with anti-B-cell rituximab.)

Or would it be better to create a couple of new list pages: List of B cell-mediated autoimmune diseases and List of T cell-mediated autoimmune diseases? 70.137.153.32 23:33, 19 October 2007 (UTC)

I think your suggestion to add a new column is a good one, though I'd encourage you to include references for the type wherever possible. It appears that you're knowledgeable about the subject, but new to Wikipedia, so if you need help, an overview on citation is available at Wikipedia:Manual_of_Style_(medicine-related_articles)#Citing_medical_sources. And if you need any assistance, feel free to ask at my talk page. --Arcadian 00:34, 20 October 2007 (UTC)

While Myositis is a rare autoimmune disease, I think it should be included on the list. There are several forms of this disease - polyomyositis, dermatomyositis, IBM and juvenile dermatomyositis. The main symptoms are muscle weakness and extreme fatigue. In the dermatomyositis form the immune system attacks both the skin and the muscles (in some cases, this includes the lung and the heart). Because the disease is so rare, many doctors are unfamiliar with the disease and diagnosis can take a significant amount of time. In my case, I was lucky, I was able to go the National Institute of Health and Johns Hopkins. —Preceding unsigned comment added by 68.55.228.107 (talk) 23:11, 24 October 2007 (UTC)

[edit] Optic neuritis

Is this really considered an A.I. disease? Or even a distinct disease? Inclusion in "confirmed" list seems most dubious....io_editor (talk) 03:05, 2 April 2008 (UTC)

I agree. Those conditions without sources should be removed, or at least bumped down. --Arcadian (talk) 20:08, 2 April 2008 (UTC)
Deleted it. Of the others, [aplastic anemia] should definitely be removed or demoted, not sure which way to go?....io_editor (talk) 01:01, 3 April 2008 (UTC)

[edit] mistake

Warm autoimmune hemolytic anemia as it is said on page for this disease is IgG conducted sometimes IgA, IgM antibody is used in cold autoimmune hemolytic anemia.Rakamijan (talk) 00:12, 23 April 2008 (UTC)

[edit] Disease causation

"Autoimmune diseases are a major cause of immune-mediated diseases." If you follow the link to immune-mediated diseases, it says that autoimmune disease are a subset of immune-mediated diseases. So the statement is like saying "green widgets are a major cause of widgets." That's hard to fathom. Unfree (talk) 22:30, 28 April 2008 (UTC)