ATP diphosphatase

From Wikipedia, the free encyclopedia

In enzymology, an ATP diphosphatase (EC 3.6.1.8) is an enzyme that catalyzes the chemical reaction

ATP + H₂O AMP + diphosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are AMP and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is ATP diphosphohydrolase (diphosphate-forming). Other names in common use include ATPase, ATP pyrophosphatase, adenosine triphosphate pyrophosphatase, and ATP diphosphohydrolase [ambiguous]. This enzyme participates in purine metabolism and pyrimidine metabolism.

[edit] References

• IUBMB entry for 3.6.1.8
• BRENDA references for 3.6.1.8 (Recommended.)
• PubMed references for 3.6.1.8
• PubMed Central references for 3.6.1.8
• Google Scholar references for 3.6.1.8
• HEPPEL LA, HILMOE RJ (1953). "Mechanism of enzymatic hydrolysis of adenosinetriphosphate". J. Biol. Chem. 202: 217–26. PMID 13061448. 
• JOHNSON M, KAYE MA, HEMS R, KREBS HA (1953). "Enzymic hydrolysis of adenosine phosphates by cobra venom". Biochem. J. 54: 625–9. PMID 13058963. 

[edit] External links

The CAS registry number for this enzyme class is 37289-25-1.

• IUBMB entry for 3.6.1.8

• KEGG entry for 3.6.1.8

• BRENDA entry for 3.6.1.8

• NiceZyme view of 3.6.1.8

• EC2PDB: PDB structures for 3.6.1.8

• PRIAM entry for 3.6.1.8

• PUMA2 entry for 3.6.1.8

• IntEnz: Integrated Enzyme entry for 3.6.1.8

• MetaCyc entry for 3.6.1.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047693: ATP diphosphatase

• AMIGO entry for GO code 0047693: ATP diphosphatase