ATP6V1C2

From Wikipedia, the free encyclopedia

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

Identifiers

ATP6V1C2; ATP6C2; VMA5

External IDs

MGI: 1916025 HomoloGene: 15866

Gene ontology
Molecular Function:	• ATP binding • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Cellular Component:	• proton-transporting two-sector ATPase complex
Biological Process:	• ATP synthesis coupled proton transport

Orthologs

Human

Mouse

Refseq

NM_001039362 (mRNA)
NP_001034451 (protein)

NM_133699 (mRNA)
NP_598460 (protein)

Location

Chr 2: 10.78 - 10.84 Mb

Chr 12: 17.31 - 17.35 Mb

Pubmed search

[1]

[2]

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2, also known as ATP6V1C2, is a human gene.^[1]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms.^[1]