ATP6AP2

From Wikipedia, the free encyclopedia

ATPase, H+ transporting, lysosomal accessory protein 2

Identifiers

ATP6AP2; APT6M8-9; ATP6IP2; ATP6M8-9; ELDF10; HT028; M8-9; MGC99577; MRXE; MSTP009; XMRE

External IDs

OMIM: 300556 MGI: 1917745 HomoloGene: 38097

Gene ontology
Molecular Function:	• receptor activity • protein binding
Cellular Component:	• external side of plasma membrane • membrane • integral to membrane
Biological Process:	• angiotensin maturation • regulation of MAPKKK cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005765 (mRNA)
NP_005756 (protein)

NM_027439 (mRNA)
NP_081715 (protein)

Location

Chr X: 40.33 - 40.35 Mb

Chr X: 11.74 - 11.77 Mb

Pubmed search

[1]

[2]

ATPase, H+ transporting, lysosomal accessory protein 2, also known as ATP6AP2, is a human gene.^[1]

This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2.

[edit] Further reading

Kaneshiro Y, Ichihara A, Sakoda M, et al. (2007). "Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats.". J. Am. Soc. Nephrol. 18 (6): 1789–95. doi:10.1681/ASN.2006091062. PMID 17494887.
Schefe JH, Menk M, Reinemund J, et al. (2007). "A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein.". Circ. Res. 99 (12): 1355–66. doi:10.1161/01.RES.0000251700.00994.0d. PMID 17082479.
Kaneshiro Y, Ichihara A, Takemitsu T, et al. (2006). "Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats.". Kidney Int. 70 (4): 641–6. doi:10.1038/sj.ki.5001627. PMID 16807542.
Burcklé CA, Jan Danser AH, Müller DN, et al. (2006). "Elevated blood pressure and heart rate in human renin receptor transgenic rats.". Hypertension 47 (3): 552–6. doi:10.1161/01.HYP.0000199912.47657.04. PMID 16401765.
Huang Y, Wongamorntham S, Kasting J, et al. (2006). "Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.". Kidney Int. 69 (1): 105–13. doi:10.1038/sj.ki.5000011. PMID 16374430.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Ramser J, Abidi FE, Burckle CA, et al. (2005). "A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor.". Hum. Mol. Genet. 14 (8): 1019–27. doi:10.1093/hmg/ddi094. PMID 15746149.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nguyen G, Delarue F, Burcklé C, et al. (2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.". J. Clin. Invest. 109 (11): 1417–27. PMID 12045255.
Hedera P, Alvarado D, Beydoun A, Fink JK (2002). "Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4.". Ann. Neurol. 51 (1): 45–50. PMID 11782983.
Demirci FY, White NJ, Rigatti BW, et al. (2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4).". Mol. Vis. 7: 234–9. PMID 11590366.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Ludwig J, Kerscher S, Brandt U, et al. (1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules.". J. Biol. Chem. 273 (18): 10939–47. PMID 9556572.