ATP6AP1

From Wikipedia, the free encyclopedia

ATPase, H+ transporting, lysosomal accessory protein 1

Identifiers

ATP6AP1; 16A; ATP6IP1; ATP6S1; Ac45; CF2; MGC129781; VATPS1; XAP-3; XAP3

External IDs

OMIM: 300197 MGI: 109629 HomoloGene: 914

Gene ontology
Molecular Function:	• nucleotide binding • fibroblast growth factor receptor binding • transporter activity • ATP binding • growth factor activity • heparin binding • hydrolase activity • metal ion binding • hydrogen ion transporting ATP synthase activity, rotational mechanism • hydrogen ion transporting ATPase activity, rotational mechanism
Cellular Component:	• nucleus • vacuole • cell surface • membrane • proton-transporting two-sector ATPase complex
Biological Process:	• protein import into nucleus, translocation • ion transport • response to stress • fibroblast growth factor receptor signaling pathway • ATP synthesis coupled proton transport • proton transport • embryonic limb morphogenesis • regulation of transcription • positive regulation of receptor mediated endocytosis • positive regulation of urothelial cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001183 (mRNA)
NP_001174 (protein)

XM_903723 (mRNA)
XP_908816 (protein)

Location

Chr X: 153.31 - 153.32 Mb

Chr X: 70.55 - 70.56 Mb

Pubmed search

[1]

[2]

ATPase, H+ transporting, lysosomal accessory protein 1, also known as ATP6AP1, is a human gene.^[1]

This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1.

[edit] Further reading

Finbow ME, Harrison MA (1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes.". Biochem. J. 324 ( Pt 3): 697-712. PMID 9210392.
Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase.". Annu. Rev. Cell Dev. Biol. 13: 779-808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
Nelson N, Harvey WR (1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases.". Physiol. Rev. 79 (2): 361-85. PMID 10221984.
Forgac M (1999). "Structure and properties of the vacuolar (H+)-ATPases.". J. Biol. Chem. 274 (19): 12951-4. PMID 10224039.
Kane PM (1999). "Introduction: V-ATPases 1992-1998.". J. Bioenerg. Biomembr. 31 (1): 3-5. PMID 10340843.
Wieczorek H, Brown D, Grinstein S, et al. (1999). "Animal plasma membrane energization by proton-motive V-ATPases.". Bioessays 21 (8): 637-48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860.
Yokoi H, Hadano S, Kogi M, et al. (1994). "Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection.". Genomics 20 (3): 404-11. doi:10.1006/geno.1994.1194. PMID 8034313.
Sedlacek Z, Korn B, Konecki DS, et al. (1994). "Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection.". Hum. Mol. Genet. 2 (11): 1865-9. PMID 8281148.
Chen EY, Zollo M, Mazzarella R, et al. (1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.". Hum. Mol. Genet. 5 (5): 659-68. PMID 8733135.
Holthuis JC, Jansen EJ, Schoonderwoert VT, et al. (1999). "Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary.". Eur. J. Biochem. 262 (2): 484-91. PMID 10336633.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Bagai S, Rubio E, Cheng JF, et al. (2002). "Fibroblast growth factor-10 is a mitogen for urothelial cells.". J. Biol. Chem. 277 (26): 23828-37. doi:10.1074/jbc.M201658200. PMID 11923311.
Hodi FS, Schmollinger JC, Soiffer RJ, et al. (2002). "ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6919-24. doi:10.1073/pnas.102025999. PMID 11983866.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.