ATG4A

From Wikipedia, the free encyclopedia

ATG4 autophagy related 4 homolog A (S. cerevisiae)

PDB rendering based on 2p82.

Available structures: 2p82

Identifiers

Symbol(s)

ATG4A; APG4A; AUTL2

External IDs

MGI: 2147903 HomoloGene: 70873

Gene ontology
Molecular Function:	• protein binding • microtubule binding • cysteine-type peptidase activity
Cellular Component:	• cytoplasm • cytosol • microtubule associated complex
Biological Process:	• autophagic vacuole formation • proteolysis • ubiquitin cycle • protein targeting to membrane • protein targeting to vacuole • autophagy • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_052936 (mRNA)
NP_443168 (protein)

XM_979883 (mRNA)
XP_984977 (protein)

Location

Chr X: 107.22 - 107.28 Mb

n/a

Pubmed search

[1]

[2]

ATG4 autophagy related 4 homolog A (S. cerevisiae), also known as ATG4A, is a human gene.^[1]

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae).

[edit] Further reading

Scherz-Shouval R, Shvets E, Fass E, et al. (2007). "Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.". EMBO J. 26 (7): 1749–60. doi:10.1038/sj.emboj.7601623. PMID 17347651.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kabeya Y, Mizushima N, Yamamoto A, et al. (2005). "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.". J. Cell. Sci. 117 (Pt 13): 2805–12. doi:10.1242/jcs.01131. PMID 15169837.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A.". J. Biol. Chem. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.
Mariño G, Uría JA, Puente XS, et al. (2003). "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.". J. Biol. Chem. 278 (6): 3671–8. doi:10.1074/jbc.M208247200. PMID 12446702.