ASF1A

From Wikipedia, the free encyclopedia

ASF1 anti-silencing function 1 homolog A (S. cerevisiae)

PDB rendering based on 1tey.

Available structures: 1tey, 2i32, 2iij, 2io5

Identifiers

Symbol(s)

ASF1A; CGI-98; CIA; DKFZP547E2110; HSPC146

External IDs

OMIM: 609189 MGI: 1913653 HomoloGene: 8528

Gene ontology
Molecular Function:	• chromatin binding • histone binding
Cellular Component:	• nucleus • chromatin remodeling complex
Biological Process:	• DNA repair • nucleosome assembly • loss of chromatin silencing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014034 (mRNA)
NP_054753 (protein)

NM_025541 (mRNA)
NP_079817 (protein)

Location

Chr 6: 119.26 - 119.27 Mb

Chr 10: 53.29 - 53.3 Mb

Pubmed search

[1]

[2]

ASF1 anti-silencing function 1 homolog A (S. cerevisiae), also known as ASF1A, is a human gene.^[1]

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.^[1]

[edit] References

^ ^a ^b Entrez Gene: ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae).

[edit] Further reading

Munakata T, Adachi N, Yokoyama N, et al. (2000). "A human homologue of yeast anti-silencing factor has histone chaperone activity.". Genes Cells 5 (3): 221–33. PMID 10759893.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. PMID 10810093.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Silljé HH, Nigg EA (2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.". Curr. Biol. 11 (13): 1068–73. PMID 11470414.
Mello JA, Silljé HH, Roche DM, et al. (2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway.". EMBO Rep. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMID 11897662.
Chimura T, Kuzuhara T, Horikoshi M (2002). "Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID.". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9334–9. doi:10.1073/pnas.142627899. PMID 12093919.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Umehara T, Horikoshi M (2003). "Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis.". J. Biol. Chem. 278 (37): 35660–7. doi:10.1074/jbc.M303549200. PMID 12842904.
Tagami H, Ray-Gallet D, Almouzni G, Nakatani Y (2004). "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.". Cell 116 (1): 51–61. PMID 14718166.
Mousson F, Couprie J, Thuret JY, et al. (2005). "1H, 13C and 15N resonance assignments of the conserved core of hAsf1 A.". J. Biomol. NMR 29 (3): 413–4. doi:10.1023/B:JNMR.0000032497.24661.44. PMID 15213445.
Zhang R, Poustovoitov MV, Ye X, et al. (2005). "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA.". Dev. Cell 8 (1): 19–30. doi:10.1016/j.devcel.2004.10.019. PMID 15621527.
Groth A, Ray-Gallet D, Quivy JP, et al. (2005). "Human Asf1 regulates the flow of S phase histones during replicational stress.". Mol. Cell 17 (2): 301–11. doi:10.1016/j.molcel.2004.12.018. PMID 15664198.
Mousson F, Lautrette A, Thuret JY, et al. (2005). "Structural basis for the interaction of Asf1 with histone H3 and its functional implications.". Proc. Natl. Acad. Sci. U.S.A. 102 (17): 5975–80. doi:10.1073/pnas.0500149102. PMID 15840725.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Tang Y, Poustovoitov MV, Zhao K, et al. (2006). "Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly.". Nat. Struct. Mol. Biol. 13 (10): 921–9. doi:10.1038/nsmb1147. PMID 16980972.
Sen SP, De Benedetti A (2006). "TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1.". BMC Mol. Biol. 7: 37. doi:10.1186/1471-2199-7-37. PMID 17054786.
Agez M, Chen J, Guerois R, et al. (2007). "Structure of the histone chaperone ASF1 bound to the histone H3 C-terminal helix and functional insights.". Structure 15 (2): 191–9. doi:10.1016/j.str.2007.01.002. PMID 17292837.
Natsume R, Eitoku M, Akai Y, et al. (2007). "Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4.". Nature 446 (7133): 338–41. doi:10.1038/nature05613. PMID 17293877.