ASCL2

From Wikipedia, the free encyclopedia

Achaete-scute complex homolog 2 (Drosophila)

Identifiers

ASCL2; ASH2; HASH2; MASH2

External IDs

OMIM: 601886 MGI: 96920 HomoloGene: 3789

Gene ontology
Molecular Function:	• transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • central nervous system development • peripheral nervous system development • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005170 (mRNA)
NP_005161 (protein)

NM_008554 (mRNA)
NP_032580 (protein)

Location

Chr 11: 2.25 - 2.25 Mb

Chr 7: 142.78 - 142.78 Mb

Pubmed search

[1]

[2]

Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene.^[1]

This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.^[1]

[edit] References

^ ^a ^b Entrez Gene: ASCL2 achaete-scute complex homolog 2 (Drosophila).

[edit] Further reading

Miyamoto T, Jinno Y, Sasaki T, et al. (1996). "Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2).". Cytogenet. Cell Genet. 73 (4): 312–4. PMID 8751384.
Alders M, Hodges M, Hadjantonakis AK, et al. (1997). "The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts.". Hum. Mol. Genet. 6 (6): 859–67. PMID 9175731.
Miyamoto T, Jinno Y, Miura K, et al. (1998). "A SacII polymorphism in the human ASCL2 (HASH2) gene region.". J. Hum. Genet. 43 (1): 69–70. PMID 9610003.
Onions J, Hermann S, Grundström T (2000). "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors.". Biochemistry 39 (15): 4366–74. PMID 10757985.
Westerman BA, Poutsma A, Looijenga LH, et al. (2001). "The Human Achaete Scute Homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization.". Placenta 22 (6): 511–8. doi:10.1053/plac.2001.0695. PMID 11440538.
Miyamoto T, Hasuike S, Jinno Y, et al. (2002). "The human ASCL2 gene escaping genomic imprinting and its expression pattern.". J. Assist. Reprod. Genet. 19 (5): 240–4. PMID 12099555.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Goo YH, Sohn YC, Kim DH, et al. (2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.". Mol. Cell. Biol. 23 (1): 140–9. PMID 12482968.
Jiang B, Mendelson CR (2003). "USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia.". Mol. Cell. Biol. 23 (17): 6117–28. PMID 12917334.
Koide S, Yoshida I, Tsuji A, Matsuda Y (2004). "The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2.". J. Biochem. 134 (3): 433–40. PMID 14561729.
Jubb AM, Chalasani S, Frantz GD, et al. (2006). "Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia.". Oncogene 25 (24): 3445–57. doi:10.1038/sj.onc.1209382. PMID 16568095.
Shahib MN, Martaadisoebrata D, Kato H (2007). "Detection of HASH2 (ASCL2) gene expression in gestational trophoblastic disease.". The Journal of reproductive medicine 51 (11): 892–6. PMID 17165436.