ASB3

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Ankyrin repeat and SOCS box-containing 3
Identifiers
Symbol(s) ASB3; ASB-3; FLJ10123; FLJ10421; MGC12531; MGC132002; MGC996
External IDs OMIM: 605760 MGI: 1929749 HomoloGene: 9391
Orthologs
Human Mouse
Entrez 51130 65257
Ensembl ENSG00000115239 ENSMUSG00000020305
Uniprot Q9Y575 Q5SSV5
Refseq NM_016115 (mRNA)
NP_057199 (protein)		 NM_023906 (mRNA)
NP_076395 (protein)
Location Chr 2: 53.75 - 53.87 Mb Chr 11: 30.85 - 31 Mb
Pubmed search [1] [2]

Ankyrin repeat and SOCS box-containing 3, also known as ASB3, is a human gene.[1]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.[1]

[edit] References

  1. ^ a b Entrez Gene: ASB3 ankyrin repeat and SOCS box-containing 3.

[edit] Further reading

  • Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235-41. PMID 12076535. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Kile BT, Viney EM, Willson TA, et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.". Gene 258 (1-2): 31-41. PMID 11111040. 
  • Kile BT, Metcalf D, Mifsud S, et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice.". Mol. Cell. Biol. 21 (18): 6189-97. PMID 11509662. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Chung AS, Guan YJ, Yuan ZL, et al. (2005). "Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II.". Mol. Cell. Biol. 25 (11): 4716-26. doi:10.1128/MCB.25.11.4716-4726.2005. PMID 15899873. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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