ASB1

From Wikipedia, the free encyclopedia

Ankyrin repeat and SOCS box-containing 1

Identifiers

ASB1; ASB-1; KIAA1146; MGC11165

External IDs

OMIM: 605758 MGI: 1929735 HomoloGene: 9390

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• intracellular
Biological Process:	• intracellular signaling cascade • multicellular organismal development • negative regulation of cytokine biosynthetic process

Orthologs

Human

Mouse

Refseq

NM_001040445 (mRNA)
NP_001035535 (protein)

NM_001039126 (mRNA)
NP_001034215 (protein)

Location

Chr 2: 239 - 239.02 Mb

Chr 1: 93.37 - 93.39 Mb

Pubmed search

[1]

[2]

Ankyrin repeat and SOCS box-containing 1, also known as ASB1, is a human gene.^[1]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation.^[1]

[edit] References

^ ^a ^b Entrez Gene: ASB1 ankyrin repeat and SOCS box-containing 1.

[edit] Further reading

Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235-41. PMID 12076535.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kile BT, Metcalf D, Mifsud S, et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice.". Mol. Cell. Biol. 21 (18): 6189-97. PMID 11509662.
Kile BT, Viney EM, Willson TA, et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.". Gene 258 (1-2): 31-41. PMID 11111040.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329-36. PMID 10574461.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.