Arylmalonate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, an arylmalonate decarboxylase (EC 4.1.1.76) is an enzyme that catalyzes the chemical reaction

2-aryl-2-methylmalonate 2-arylpropanoate + CO₂

Hence, this enzyme has one substrate, 2-aryl-2-methylmalonate, and two products, 2-arylpropanoate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming). Other names in common use include AMDASE, 2-aryl-2-methylmalonate carboxy-lyase, and 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropionate-forming).

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2DGD.

[edit] References

• IUBMB entry for 4.1.1.76
• BRENDA references for 4.1.1.76 (Recommended.)
• PubMed references for 4.1.1.76
• PubMed Central references for 4.1.1.76
• Google Scholar references for 4.1.1.76
• Miyamoto K, Ohta H (1992). "Cloning and heterologous expression of a novel arylmalonate decarboxylase gene from Alcaligenes bronchisepticus KU 1201". Appl. Microbiol. Biotechnol. 38: 234–8. PMID 1369144. 

[edit] External links

The CAS registry number for this enzyme class is 144713-36-0.

• IUBMB entry for 4.1.1.76

• KEGG entry for 4.1.1.76

• BRENDA entry for 4.1.1.76

• NiceZyme view of 4.1.1.76

• EC2PDB: PDB structures for 4.1.1.76

• PRIAM entry for 4.1.1.76

• PUMA2 entry for 4.1.1.76

• IntEnz: Integrated Enzyme entry for 4.1.1.76

• MetaCyc entry for 4.1.1.76

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047436: arylmalonate decarboxylase

• AMIGO entry for GO code 0047436: arylmalonate decarboxylase