Aryldialkylphosphatase

From Wikipedia, the free encyclopedia

In enzymology, an aryldialkylphosphatase (EC 3.1.8.1) is an enzyme that catalyzes the chemical reaction

an aryl dialkyl phosphate + H₂O dialkyl phosphate + an aryl alcohol

Thus, the two substrates of this enzyme are aryl dialkyl phosphate and H₂O, whereas its two products are dialkyl phosphate and aryl alcohol.

This enzyme belongs to the family of hydrolases, specifically those acting on ester bonds phosphoric-triester hydrolases. The systematic name of this enzyme class is aryltriphosphate dialkylphosphohydrolase. Other names in common use include organophosphate hydrolase, paraoxonase, A-esterase, aryltriphosphatase, organophosphate esterase, esterase B1, esterase E4, paraoxon esterase, pirimiphos-methyloxon esterase, OPA anhydrase, organophosphorus hydrolase, phosphotriesterase, paraoxon hydrolase, OPH, and organophosphorus acid anhydrase. This enzyme participates in gamma-hexachlorocyclohexane degradation. It employs one cofactor, divalent cation. At least one compound, Chelating agent is known to inhibit this enzyme.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes 1EYW, 1EZ2, 1HZY, 1I0B, 1I0D, 1JGM, 1P6B, 1P6C, 1P9E, 1QW7, 1V04, 2D2G, 2D2H, 2D2J, and 2OB3.

[edit] References

• IUBMB entry for 3.1.8.1
• BRENDA references for 3.1.8.1 (Recommended.)
• PubMed references for 3.1.8.1
• PubMed Central references for 3.1.8.1
• Google Scholar references for 3.1.8.1
• ALDRIDGE WN (1953). "Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination". Biochem. J. 53: 110–7. PMID 13032041. 
• Bosmann HB (1972). "Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate". Biochim. Biophys. Acta. 276: 180–91. PMID 5047702. 
• Mackness MI, Thompson HM, Hardy AR, Walker CH (1987). "Distinction between 'A'-esterases and arylesterases. Implications for esterase classification". Biochem. J. 245: 293–6. PMID 2822017. 
• Main AR (1960). "The differentiation of the A-type esterases in sheep serum". Biochem. J. 75: 188–195. 
• UK, 1989. "". 

[edit] External links

The CAS registry number for this enzyme class is 117698-12-1.

• IUBMB entry for 3.1.8.1

• KEGG entry for 3.1.8.1

• BRENDA entry for 3.1.8.1

• NiceZyme view of 3.1.8.1

• EC2PDB: PDB structures for 3.1.8.1

• PRIAM entry for 3.1.8.1

• PUMA2 entry for 3.1.8.1

• IntEnz: Integrated Enzyme entry for 3.1.8.1

• MetaCyc entry for 3.1.8.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004063: aryldialkylphosphatase

• AMIGO entry for GO code 0004063: aryldialkylphosphatase