Aryl sulfotransferase

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In enzymology, an aryl sulfotransferase (EC 2.8.2.1) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + a phenol $\rightleftharpoons$ adenosine 3',5'-bisphosphate + an aryl sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and phenol, whereas its two products are adenosine 3',5'-bisphosphate and aryl sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:phenol sulfotransferase. Other names in common use include phenol sulfotransferase, sulfokinase, 1-naphthol phenol sulfotransferase, 2-naphtholsulfotransferase, 4-nitrocatechol sulfokinase, arylsulfotransferase, dopamine sulfotransferase, p-nitrophenol sulfotransferase, phenol sulfokinase, ritodrine sulfotransferase, and PST. This enzyme participates in sulfur metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1LS6, 1Z28, 1Z29, 2A3R, and 2D06.

[edit] References

IUBMB entry for 2.8.2.1
BRENDA references for 2.8.2.1 (Recommended.)
PubMed references for 2.8.2.1
PubMed Central references for 2.8.2.1
Google Scholar references for 2.8.2.1
Romain Y, Demassieux S, Carriere S (1982). "Partial purification and characterization of two isoenzymes involved in the sulfurylation of catecholamines". Biochem. Biophys. Res. Commun. 106: 999–1005. doi:10.1016/0006-291X(82)91810-1. PMID 6956338.
Sekura RD, Jakoby WB (1979). "Phenol sulfotransferases". J. Biol. Chem. 254: 5658–63. PMID 447677.