Aromatic-hydroxylamine O-acetyltransferase

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In enzymology, an aromatic-hydroxylamine O-acetyltransferase (EC 2.3.1.56) is an enzyme that catalyzes the chemical reaction

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl $\rightleftharpoons$ N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Thus, the two substrates of this enzyme are N-hydroxy-4-acetylaminobiphenyl and N-hydroxy-4-aminobiphenyl, whereas its two products are N-hydroxy-4-aminobiphenyl and N-acetoxy-4-aminobiphenyl.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase. Other names in common use include aromatic hydroxylamine acetyltransferase, arylhydroxamate acyltransferase, arylhydroxamate N,O-acetyltransferase, arylhydroxamic acid N,O-acetyltransferase, arylhydroxamic acyltransferase, N,O-acetyltransferase, and N-hydroxy-2-acetylaminofluorene N-O acyltransferase.

[edit] References

IUBMB entry for 2.3.1.56
BRENDA references for 2.3.1.56 (Recommended.)
PubMed references for 2.3.1.56
PubMed Central references for 2.3.1.56
Google Scholar references for 2.3.1.56
Bartsch H, Dworkin C, Miller EC, Miller JA (1973). "Formation of electrophilic N-acetoxyarylamines in cytosoles from rat mammary gland and other tissues by transacetylation from the carcinogen N-hydroxy-4-acetylaminobiphenyl". Biochim. Biophys. Acta. 304: 42–55. PMID 4699998.