Arogenate dehydrogenase (NAD(P)+)

From Wikipedia, the free encyclopedia

In enzymology, an arogenate dehydrogenase [NAD(P)+] (EC 1.3.1.79) is an enzyme that catalyzes the chemical reaction

L-arogenate + NAD(P)+ L-tyrosine + NAD(P)H + CO₂

The 3 substrates of this enzyme are L-arogenate, NAD⁺, and NADP⁺, whereas its 4 products are L-tyrosine, NADH, NADPH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NAD(P)+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), cyclohexadienyl dehydrogenase, and pretyrosine dehydrogenase (ambiguous).

[edit] References

• IUBMB entry for 1.3.1.79
• BRENDA references for 1.3.1.79 (Recommended.)
• PubMed references for 1.3.1.79
• PubMed Central references for 1.3.1.79
• Google Scholar references for 1.3.1.79
• Connelly JA, Conn EE (1986). "Tyrosine biosynthesis in Sorghum bicolor: isolation and regulatory properties of arogenate dehydrogenase". Z. Naturforsch. [C]. 41: 69–78. PMID 2939643. 
• Bonner C, Jensen R (1987). "Arogenate dehydrogenase". Methods. Enzymol. 142: 488–94. PMID 3600376. 

[edit] External links

The CAS registry number for this enzyme class is 64295-75-6.

• IUBMB entry for 1.3.1.79

• KEGG entry for 1.3.1.79

• BRENDA entry for 1.3.1.79

• NiceZyme view of 1.3.1.79

• EC2PDB: PDB structures for 1.3.1.79

• PRIAM entry for 1.3.1.79

• PUMA2 entry for 1.3.1.79

• IntEnz: Integrated Enzyme entry for 1.3.1.79

• MetaCyc entry for 1.3.1.79

• Atomic-resolution structures of enzymes belonging to this class