ARID4B

From Wikipedia, the free encyclopedia

AT rich interactive domain 4B (RBP1-like)

Identifiers

ARID4B; BCAA; BRCAA1; DKFZp313M2420; MGC163290; RBBP1L1; RBP1L1; SAP180

External IDs

OMIM: 609696 MGI: 2137512 HomoloGene: 12847

Gene ontology
Molecular Function:	• molecular_function • nucleic acid binding • DNA binding • chromatin binding
Cellular Component:	• chromatin • cellular_component • intracellular • nucleus
Biological Process:	• chromatin assembly or disassembly • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016374 (mRNA)
NP_057458 (protein)

NM_194262 (mRNA)
NP_919238 (protein)

Location

Chr 1: 233.4 - 233.56 Mb

Chr 13: 13.91 - 13.99 Mb

Pubmed search

[1]

[2]

AT rich interactive domain 4B (RBP1-like), also known as ARID4B, is a human gene.^[1]

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like).

[edit] Further reading

Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Cao J, Gao T, Stanbridge EJ, Irie R (2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis.". J. Natl. Cancer Inst. 93 (15): 1159–65. PMID 11481388.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Bommel H, Xie G, Rossoll W, et al. (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease.". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMID 12446740.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and characterization of three new components of the mSin3A corepressor complex.". Mol. Cell. Biol. 23 (10): 3456–67. PMID 12724404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cui D, Jin G, Gao T, et al. (2004). "Characterization of BRCAA1 and its novel antigen epitope identification.". Cancer Epidemiol. Biomarkers Prev. 13 (7): 1136–45. PMID 15247124.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.