ARHGDIA

From Wikipedia, the free encyclopedia

Rho GDP dissociation inhibitor (GDI) alpha

PDB rendering based on 1ajw.

Available structures: 1ajw, 1cc0, 1doa, 1fso, 1fst, 1ft0, 1ft3, 1gdf, 1hh4, 1kmt, 1qvy, 1rho, 2bxw, 2jhs, 2jht, 2jhu, 2jhv, 2jhw, 2jhx, 2jhy, 2jhz, 2ji0

Identifiers

Symbol(s)

ARHGDIA; GDIA1; MGC117248; RHOGDI; RHOGDI-1

External IDs

OMIM: 601925 MGI: 2178103 HomoloGene: 908

Gene ontology
Molecular Function:	• Rho GDP-dissociation inhibitor activity • GTPase activator activity • protein binding
Cellular Component:	• immunological synapse • cytoplasm • cytoskeleton
Biological Process:	• anti-apoptosis • cell motility • negative regulation of cell adhesion • Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004309 (mRNA)
NP_004300 (protein)

NM_133796 (mRNA)
NP_598557 (protein)

Location

Chr 17: 77.42 - 77.42 Mb

Chr 11: 120.39 - 120.4 Mb

Pubmed search

[1]

[2]

Rho GDP dissociation inhibitor (GDI) alpha, also known as ARHGDIA, is a human gene.^[1]

[edit] References

^ Entrez Gene: ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha.

[edit] Further reading

Leffers H, Nielsen MS, Andersen AH, et al. (1994). "Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton.". Exp. Cell Res. 209 (2): 165–74. doi:10.1006/excr.1993.1298. PMID 8262133.
Wagner T, Tommerup N, Wirth J, et al. (1997). "A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3.". Cytogenet. Cell Genet. 76 (3-4): 172–5. PMID 9186513.
Keep NH, Barnes M, Barsukov I, et al. (1997). "A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.". Structure 5 (5): 623–33. PMID 9195882.
Takahashi K, Sasaki T, Mammoto A, et al. (1997). "Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein.". J. Biol. Chem. 272 (37): 23371–5. PMID 9287351.
Gorvel JP, Chang TC, Boretto J, et al. (1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity.". FEBS Lett. 422 (2): 269–73. PMID 9490022.
Takahashi K, Sasaki T, Mammoto A, et al. (1998). "Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl.". Oncogene 16 (25): 3279–84. doi:10.1038/sj.onc.1201874. PMID 9681826.
Newcombe AR, Stockley RW, Hunter JL, Webb MR (1999). "The interaction between rac1 and its guanine nucleotide dissociation inhibitor (GDI), monitored by a single fluorescent coumarin attached to GDI.". Biochemistry 38 (21): 6879–86. doi:10.1021/bi9829837. PMID 10346909.
Groysman M, Russek CS, Katzav S (2000). "Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation.". FEBS Lett. 467 (1): 75–80. PMID 10664460.
Lian LY, Barsukov I, Golovanov AP, et al. (2000). "Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1.". Structure 8 (1): 47–55. PMID 10673424.
Hoffman GR, Nassar N, Cerione RA (2000). "Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.". Cell 100 (3): 345–56. PMID 10676816.
Matarrese P, Conti L, Varano B, et al. (2000). "The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly.". Cell Death Differ. 7 (1): 25–36. doi:10.1038/sj.cdd.4400616. PMID 10713718.
Michaelson D, Silletti J, Murphy G, et al. (2001). "Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding.". J. Cell Biol. 152 (1): 111–26. PMID 11149925.
Longenecker KL, Garrard SM, Sheffield PJ, Derewenda ZS (2001). "Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI.". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 5): 679–88. PMID 11320308.
Grizot S, Fauré J, Fieschi F, et al. (2001). "Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation.". Biochemistry 40 (34): 10007–13. PMID 11513578.
Di-Poï N, Fauré J, Grizot S, et al. (2001). "Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex.". Biochemistry 40 (34): 10014–22. PMID 11513579.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
DerMardirossian C, Schnelzer A, Bokoch GM (2004). "Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase.". Mol. Cell 15 (1): 117–27. doi:10.1016/j.molcel.2004.05.019. PMID 15225553.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Dransart E, Morin A, Cherfils J, Olofsson B (2005). "Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.". J. Biol. Chem. 280 (6): 4674–83. doi:10.1074/jbc.M409741200. PMID 15513926.
Gajate C, Mollinedo F (2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy.". J. Biol. Chem. 280 (12): 11641–7. doi:10.1074/jbc.M411781200. PMID 15659383.