ARHGAP4

From Wikipedia, the free encyclopedia

Rho GTPase activating protein 4

Identifiers

ARHGAP4; C1; KIAA0131; RGC1; RhoGAP4; p115

External IDs

OMIM: 300023 MGI: 2159577 HomoloGene: 20403

Gene ontology
Molecular Function:	• SH3/SH2 adaptor activity • GTPase activator activity • Rho GTPase activator activity
Cellular Component:	• intracellular • cytoplasm
Biological Process:	• cytoskeleton organization and biogenesis • signal transduction • Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001666 (mRNA)
NP_001657 (protein)

NM_138630 (mRNA)
NP_619536 (protein)

Location

Chr X: 152.83 - 152.84 Mb

Chr X: 70.15 - 70.16 Mb

Pubmed search

[1]

[2]

Rho GTPase activating protein 4, also known as ARHGAP4, is a human gene.^[1]

[edit] References

^ Entrez Gene: ARHGAP4 Rho GTPase activating protein 4.

[edit] Further reading

Tribioli C, Mancini M, Plassart E, et al. (1995). "Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae.". Hum. Mol. Genet. 3 (7): 1061-7. PMID 7981673.
Tribioli C, Droetto S, Bione S, et al. (1996). "An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 695-9. PMID 8570618.
Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167-74, 199-210. PMID 8590280.
Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.". Genomics 44 (1): 8-14. doi:10.1006/geno.1997.4822. PMID 9286695.
Zuber J, Tchernitsa OI, Hinzmann B, et al. (2000). "A genome-wide survey of RAS transformation targets.". Nat. Genet. 24 (2): 144-52. doi:10.1038/72799. PMID 10655059.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Demura M, Takeda Y, Yoneda T, et al. (2002). "Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus.". Hum. Mutat. 19 (1): 23-9. doi:10.1002/humu.10011. PMID 11754100.
Christerson LB, Gallagher E, Vanderbilt CA, et al. (2002). "p115 Rho GTPase activating protein interacts with MEKK1.". J. Cell. Physiol. 192 (2): 200-8. doi:10.1002/jcp.10125. PMID 12115726.
Foletta VC, Brown FD, Young WS (2003). "Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules.". Brain Res. Mol. Brain Res. 107 (1): 65-79. PMID 12414125.
Soderling SH, Binns KL, Wayman GA, et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.". Nat. Cell Biol. 4 (12): 970-5. doi:10.1038/ncb886. PMID 12447388.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.". Int. J. Mol. Med. 11 (6): 791-7. PMID 12736724.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.