Apolipoprotein D

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Apolipoprotein D
Identifiers
Symbol(s) APOD;
External IDs OMIM: 107740 MGI: 88056 HomoloGene: 1246
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 347 11815
Ensembl ENSG00000189058 ENSMUSG00000022548
Uniprot P05090 Q3TZE7
Refseq NM_001647 (mRNA)
NP_001638 (protein)		 XM_994687 (mRNA)
XP_999781 (protein)
Location Chr 3: 196.78 - 196.79 Mb Chr 16: 31.22 - 31.23 Mb
Pubmed search [1] [2]

Apolipoprotein D, also known as APOD, is a human gene.[1]

Apolipoprotein D (Apo-D) is a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. It is a glycoprotein of estimated molecular weight 33 KDa. Apo-D is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism.[1]

[edit] References

  1. ^ a b Entrez Gene: APOD apolipoprotein D.

[edit] Further reading

  • Rassart E, Bedirian A, Do Carmo S, et al. (2000). "Apolipoprotein D.". Biochim. Biophys. Acta 1482 (1-2): 185–98. PMID 11058760. 
  • Peitsch MC, Boguski MS (1991). "Is apolipoprotein D a mammalian bilin-binding protein?". New Biol. 2 (2): 197–206. PMID 2083249. 
  • Balbín M, Freije JM, Fueyo A, et al. (1990). "Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease.". Biochem. J. 271 (3): 803–7. PMID 2244881. 
  • Drayna DT, McLean JW, Wion KL, et al. (1987). "Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily.". DNA 6 (3): 199–204. PMID 2439269. 
  • Drayna D, Scott JD, Lawn R (1988). "Multiple RFLPs at the human apolipoprotein D (APOD) locus.". Nucleic Acids Res. 15 (22): 9617. PMID 2891117. 
  • Drayna D, Fielding C, McLean J, et al. (1987). "Cloning and expression of human apolipoprotein D cDNA.". J. Biol. Chem. 261 (35): 16535–9. PMID 3453108. 
  • Fielding PE, Fielding CJ (1980). "A cholesteryl ester transfer complex in human plasma.". Proc. Natl. Acad. Sci. U.S.A. 77 (6): 3327–30. PMID 6774335. 
  • Schindler PA, Settineri CA, Collet X, et al. (1995). "Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion.". Protein Sci. 4 (4): 791–803. PMID 7613477. 
  • Yang CY, Gu ZW, Blanco-Vaca F, et al. (1994). "Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links.". Biochemistry 33 (41): 12451–5. PMID 7918467. 
  • Holzfeind P, Merschak P, Dieplinger H, Redl B (1996). "The human lacrimal gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members of the lipocalin superfamily.". Exp. Eye Res. 61 (4): 495–500. PMID 8549691. 
  • Zeng C, Spielman AI, Vowels BR, et al. (1996). "A human axillary odorant is carried by apolipoprotein D.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6626–30. PMID 8692868. 
  • Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. 
  • Liu Z, Chang GQ, Leibowitz SF (2001). "Apolipoprotein D interacts with the long-form leptin receptor: a hypothalamic function in the control of energy homeostasis.". FASEB J. 15 (7): 1329–31. PMID 11344130. 
  • Sánchez D, Ganfornina MD, Martínez S (2002). "Expression pattern of the lipocalin apolipoprotein D during mouse embryogenesis.". Mech. Dev. 110 (1-2): 225–9. PMID 11744388. 
  • Mahadik SP, Khan MM, Evans DR, Parikh VV (2002). "Elevated plasma level of apolipoprotein D in schizophrenia and its treatment and outcome.". Schizophrenia Research 58 (1): 55–62. PMID 12363390. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Desai PP, Hendrie HC, Evans RM, et al. (2003). "Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 116 (1): 98–101. doi:10.1002/ajmg.b.10798. PMID 12497622. 
  • Kang MK, Kameta A, Shin KH, et al. (2003). "Senescence-associated genes in normal human oral keratinocytes.". Exp. Cell Res. 287 (2): 272–81. PMID 12837283. 
  • Thomas EA, Laws SM, Sutcliffe JG, et al. (2003). "Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype.". Biol. Psychiatry 54 (2): 136–41. PMID 12873803. 

[edit] External links

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APOA (1, 2, 5) - APOB - APOC (1, 2, 3, 4) - APOD - APOE - APOH
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