APOF

From Wikipedia, the free encyclopedia

Apolipoprotein F

Identifiers

APOF; Apo-F; DKFZp781G18150; MGC22520

External IDs

OMIM: 107760 MGI: 104539 HomoloGene: 48030

Gene ontology
Molecular Function:	• receptor binding • lipid transporter activity • high-density lipoprotein binding • cholesterol binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• lipid metabolic process • lipid transport • steroid metabolic process • cholesterol metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001638 (mRNA)
NP_001629 (protein)

NM_133997 (mRNA)
NP_598758 (protein)

Location

Chr 12: 55.04 - 55.06 Mb

Chr 10: 127.67 - 127.67 Mb

Pubmed search

[1]

[2]

Apolipoprotein F, also known as APOF, is a human gene.^[1]

The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol.^[1]

[edit] References

^ ^a ^b Entrez Gene: APOF apolipoprotein F.

[edit] Further reading

Morton RE, Gnizak HM, Greene DJ, et al. (2008). "Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects.". J. Lipid Res. 49 (1): 127–35. doi:10.1194/jlr.M700258-JLR200. PMID 17901467.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kabbara A, Payet N, Cottel D, et al. (2004). "Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population.". Neurosci. Lett. 363 (2): 139–43. doi:10.1016/j.neulet.2004.03.066. PMID 15172102.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Paromov VM, Morton RE (2003). "Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP).". J. Biol. Chem. 278 (42): 40859–66. doi:10.1074/jbc.M306580200. PMID 12907677.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wang X, Driscoll DM, Morton RE (1999). "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F.". J. Biol. Chem. 274 (3): 1814–20. PMID 9880564.
Day JR, Albers JJ, Gilbert TL, et al. (1994). "Purification and molecular cloning of human apolipoprotein F.". Biochem. Biophys. Res. Commun. 203 (2): 1146–51. doi:10.1006/bbrc.1994.2302. PMID 8093033.
Koren E, McConathy WJ, Alaupovic P (1983). "Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma.". Biochemistry 21 (21): 5347–51. PMID 6816269.
Olofsson SO, McConathy WJ, Alaupovic P (1978). "Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma.". Biochemistry 17 (6): 1032–6. PMID 204339.