APLP2

From Wikipedia, the free encyclopedia

Amyloid beta (A4) precursor-like protein 2

Identifiers

APLP2; APPH; APPL2; CDEBP

External IDs

Gene ontology
Molecular Function:	• DNA binding • serine-type endopeptidase inhibitor activity • binding • protein binding
Cellular Component:	• nucleus • membrane • integral to membrane
Biological Process:	• G-protein coupled receptor protein signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001642 (mRNA)
NP_001633 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 11: 129.45 - 129.52 Mb

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Pubmed search

[1]

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Amyloid beta (A4) precursor-like protein 2, also known as APLP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: APLP2 Amyloid beta (A4) precursor-like protein 2.

[edit] Further reading

Blangy A, Vidal F, Cuzin F, et al. (1995). "CDEBP, a site-specific DNA-binding protein of the 'APP-like' family, is required during the early development of the mouse.". J. Cell. Sci. 108 ( Pt 2): 675–83. PMID 7539437.
von der Kammer H, Hanes J, Klaudiny J, Scheit KH (1995). "A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein.". DNA Cell Biol. 13 (11): 1137–43. PMID 7702756.
Bush AI, Pettingell WH, de Paradis M, et al. (1994). "The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.". J. Biol. Chem. 269 (43): 26618–21. PMID 7929392.
von der Kammer H, Löffler C, Hanes J, et al. (1994). "The gene for the amyloid precursor-like protein APLP2 is assigned to human chromosome 11q23-q25.". Genomics 20 (2): 308–11. doi:10.1006/geno.1994.1174. PMID 8020984.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Wasco W, Gurubhagavatula S, Paradis MD, et al. (1993). "Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.". Nat. Genet. 5 (1): 95–100. doi:10.1038/ng0993-95. PMID 8220435.
Sprecher CA, Grant FJ, Grimm G, et al. (1993). "Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family.". Biochemistry 32 (17): 4481–6. PMID 8485127.
Guénette SY, Chen J, Jondro PD, Tanzi RE (1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10832–7. PMID 8855266.
Bressler SL, Gray MD, Sopher BL, et al. (1997). "cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.". Hum. Mol. Genet. 5 (10): 1589–98. PMID 8894693.
Suzuki T, Ando K, Isohara T, et al. (1997). "Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.". Biochemistry 36 (15): 4643–9. doi:10.1021/bi962618k. PMID 9109675.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Duilio A, Faraonio R, Minopoli G, et al. (1998). "Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.". Biochem. J. 330 ( Pt 1): 513–9. PMID 9461550.
Lyckman AW, Confaloni AM, Thinakaran G, et al. (1998). "Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system.". J. Biol. Chem. 273 (18): 11100–6. PMID 9556595.
Tanahashi H, Tabira T (1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.". Neurosci. Lett. 261 (3): 143–6. PMID 10081969.
Homayouni R, Rice DS, Sheldon M, Curran T (1999). "Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.". J. Neurosci. 19 (17): 7507–15. PMID 10460257.
Mitsuuchi Y, Johnson SW, Sonoda G, et al. (1999). "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.". Oncogene 18 (35): 4891–8. doi:10.1038/sj.onc.1203080. PMID 10490823.
Leach R, Ko M, Krawetz SA (2000). "Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization.". Cytogenet. Cell Genet. 87 (3-4): 215–6. PMID 10702673.
Xu KP, Zoukhri D, Zieske JD, et al. (2001). "A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells.". Am. J. Physiol., Cell Physiol. 281 (2): C603–14. PMID 11443060.
Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening.". J. Cell. Biochem. 83 (4): 521–31. PMID 11746496.
Scheinfeld MH, Ghersi E, Laky K, et al. (2003). "Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription.". J. Biol. Chem. 277 (46): 44195–201. doi:10.1074/jbc.M208110200. PMID 12228233.