APLP1

From Wikipedia, the free encyclopedia

Amyloid beta (A4) precursor-like protein 1

Identifiers

External IDs

OMIM: 104775 MGI: 88046 HomoloGene: 68447

Gene ontology
Molecular Function:	• copper ion binding • protein binding • heparin binding • zinc ion binding • metal ion binding
Cellular Component:	• basement membrane • membrane fraction • plasma membrane • coated pit • integral to membrane
Biological Process:	• mRNA polyadenylation • endocytosis • apoptosis • cell adhesion • nervous system development • cell death • organ morphogenesis • extracellular matrix organization and biogenesis • forebrain development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001024807 (mRNA)
NP_001019978 (protein)

XM_994141 (mRNA)
XP_999235 (protein)

Location

Chr 19: 41.05 - 41.06 Mb

Chr 7: 30.14 - 30.15 Mb

Pubmed search

[1]

[2]

Amyloid beta (A4) precursor-like protein 1, also known as APLP1, is a human gene.^[1]

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: APLP1 amyloid beta (A4) precursor-like protein 1.

[edit] Further reading

Bayer TA, Cappai R, Masters CL, et al. (2000). "It all sticks together--the APP-related family of proteins and Alzheimer's disease.". Mol. Psychiatry 4 (6): 524-8. PMID 10578233.
Kim TW, Wu K, Xu JL, et al. (1996). "Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density.". Brain Res. Mol. Brain Res. 32 (1): 36-44. PMID 7494461.
Bush AI, Pettingell WH, de Paradis M, et al. (1994). "The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.". J. Biol. Chem. 269 (43): 26618-21. PMID 7929392.
Wasco W, Brook JD, Tanzi RE (1993). "The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19.". Genomics 15 (1): 237-9. doi:10.1006/geno.1993.1047. PMID 8432545.
Bressler SL, Gray MD, Sopher BL, et al. (1997). "cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.". Hum. Mol. Genet. 5 (10): 1589-98. PMID 8894693.
Paliga K, Peraus G, Kreger S, et al. (1998). "Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.". Eur. J. Biochem. 250 (2): 354-63. PMID 9428684.
Lenkkeri U, Kestilä M, Lamerdin J, et al. (1998). "Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1.". Hum. Genet. 102 (2): 192-6. PMID 9521588.
McNamara MJ, Ruff CT, Wasco W, et al. (1998). "Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.". Brain Res. 804 (1): 45-51. PMID 9729270.
Tomita S, Ozaki T, Taru H, et al. (1999). "Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.". J. Biol. Chem. 274 (4): 2243-54. PMID 9890987.
Homayouni R, Rice DS, Sheldon M, Curran T (1999). "Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.". J. Neurosci. 19 (17): 7507-15. PMID 10460257.
Simons A, Ruppert T, Schmidt C, et al. (2002). "Evidence for a copper-binding superfamily of the amyloid precursor protein.". Biochemistry 41 (30): 9310-20. PMID 12135352.
Scheinfeld MH, Ghersi E, Laky K, et al. (2003). "Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription.". J. Biol. Chem. 277 (46): 44195-201. doi:10.1074/jbc.M208110200. PMID 12228233.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Walsh DM, Fadeeva JV, LaVoie MJ, et al. (2003). "gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.". Biochemistry 42 (22): 6664-73. doi:10.1021/bi027375c. PMID 12779321.
Yamakami M, Yoshimori T, Yokosawa H (2004). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.". J. Biol. Chem. 278 (52): 52865-72. doi:10.1074/jbc.M306740200. PMID 14563850.
Adlerz L, Beckman M, Holback S, et al. (2004). "Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction.". Brain Res. Mol. Brain Res. 119 (1): 62-72. PMID 14597230.
Li Q, Südhof TC (2004). "Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.". J. Biol. Chem. 279 (11): 10542-50. doi:10.1074/jbc.M310001200. PMID 14699153.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Eggert S, Paliga K, Soba P, et al. (2004). "The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation.". J. Biol. Chem. 279 (18): 18146-56. doi:10.1074/jbc.M311601200. PMID 14970212.