API5

From Wikipedia, the free encyclopedia

Apoptosis inhibitor 5

Identifiers

API5; AAC-11; AAC11; API5L1

External IDs

OMIM: 609774 MGI: 1888993 HomoloGene: 4809

Gene ontology
Molecular Function:	• fibroblast growth factor binding
Cellular Component:	• nucleus • spliceosome • cytoplasm
Biological Process:	• transport • apoptosis • anti-apoptosis

Orthologs

Human

Mouse

Refseq

NM_006595 (mRNA)
NP_006586 (protein)

NM_007466 (mRNA)
NP_031492 (protein)

Location

Chr 11: 43.29 - 43.32 Mb

Chr 2: 94.21 - 94.24 Mb

Pubmed search

[1]

[2]

Apoptosis inhibitor 5, also known as API5, is a human gene.^[1]

[edit] References

^ Entrez Gene: API5 apoptosis inhibitor 5.

[edit] Further reading

Tewari M, Yu M, Ross B, et al. (1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal.". Cancer Res. 57 (18): 4063–9. PMID 9307294.
Gianfrancesco F, Esposito T, Ciccodicola A, et al. (1999). "Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene.". Cytogenet. Cell Genet. 84 (3-4): 164–6. PMID 10393420.
Kim JW, Cho HS, Kim JH, et al. (2000). "AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis.". Lab. Invest. 80 (4): 587–94. PMID 10780674.
Van den Berghe L, Laurell H, Huez I, et al. (2001). "FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2.". Mol. Endocrinol. 14 (11): 1709–24. PMID 11075807.
Sutherland HG, Mumford GK, Newton K, et al. (2001). "Large-scale identification of mammalian proteins localized to nuclear sub-compartments.". Hum. Mol. Genet. 10 (18): 1995–2011. PMID 11555636.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Li Z, Hu CY, Mo BQ, et al. (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng 22 (4): 380–4. PMID 12703993.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Morris EJ, Michaud WA, Ji JY, et al. (2006). "Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.". PLoS Genet. 2 (11): e196. doi:10.1371/journal.pgen.0020196. PMID 17112319.