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| Aphthovirus internal ribosome entry site (IRES) |
 |
| Type: |
Cis-reg; IRES; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
PubMed |
| Avg length: |
461.5 nucleotides |
| Avg identity: |
73% |
|
This family represents the internal ribosome entry site (IRES) of the the aphthoviruses.[1] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor eIF4F.[2]
[edit] References
- ^ Fernandez-Miragall, O; Martinez-Salas E (2003). "Structural organization of a viral IRES depends on the integrity of the GNRA motif". RNA 9: 1333–1344. doi:10.1261/rna.5950603. PMID 14561883.
- ^ Kolupaeva, VG; Pestova TV, Hellen CU (2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA 6: 1791–1807. doi:10.1017/S1355838200000662. PMID 11142379.
[edit] External links
