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| APC internal ribosome entry site (IRES) |
 |
| Type: |
Cis-reg; IRES; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Published; PubMed |
| Avg length: |
53.0 nucleotides |
| Avg identity: |
85% |
|
The APC internal ribosome entry site (IRES) is an RNA element which is located in the coding sequence of the APC gene. APC is a tumour suppressor gene which is associated with the inherited disease adenomatous polyposis coli (APC).It is thought that IRES-mediated translation of APC is important for an apoptotic cascade [1].
[edit] References
- [1] Heppner, Goss K; Trzepacz C, Tuohy TM, Groden J (2002). "Attenuated APC alleles produce functional protein from internal translation initiation". Proc Natl Acad Sci U S A 99: 8161–8166. doi:10.1073/pnas.112072199. PMID 12034871.
[edit] External links
