APC (protein)
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APC (adenomatosis polyposis coli) is the product of a tumor suppressor gene (APC (gene)). The human full-length protein comprises 2843 AA with a (predicted) molecular mass of 311646 Da. Most domains of this protein are solved structurally and exhibit high intrinsic disorder/flexibility as monomer and a low content of stable secondary structure. Thus it is a member of the intrinsically unstructured proteins (Intrinsically unstructured proteins). Nothing is known about in vivo full-length (un)foldome which is nice for some investigators (but bad for current therapeutic intervention) ...
[edit] List of (some ...) point mutants
L852M
P865S
S906Y
E911G
S966R
Y1027C
T1018C
S1081I
D1083E
Q1096H
E1284G
E1284K
A1305S
E1306K
K1308E
E1317Q
P1319T
S1321N
V1326M
E1353V
F1354L
G1357R
S1364R
Q1367H
P1373T
S1389F
S1389T
S1385R
L1393P
S1395C
S1398N
S1415I
D1422H
D1425A
S1434I
K1468N
G1534R
S1599L
[edit] References
Point mutants :
- PMID 12619115
- PMID 14695993
- PMID 1528264
- PMID 8395678
- PMID 12093899
- PMID 9924427
- PMID 15072829
- PMID 12833148
- PMID 8764128
- PMID 11315765
- PMID 10638959
- PMID 11819789
- PMID 8055154
- PMID 9014854
- PMID 11048797
- PMID 7881432
- PMID 9482574
- PMID 14502807
- PMID 17882487
