AP4B1

From Wikipedia, the free encyclopedia

Adaptor-related protein complex 4, beta 1 subunit

Identifiers

AP4B1; BETA-4

External IDs

OMIM: 607245 MGI: 1337130 HomoloGene: 38203

Gene ontology
Molecular Function:	• transporter activity • binding
Cellular Component:	• soluble fraction • trans-Golgi network • coated pit
Biological Process:	• protein transport

Orthologs

Human

Mouse

Refseq

NM_006594 (mRNA)
NP_006585 (protein)

NM_026193 (mRNA)
NP_080469 (protein)

Location

Chr 1: 114.24 - 114.25 Mb

Chr 3: 103.94 - 103.95 Mb

Pubmed search

[1]

[2]

Adaptor-related protein complex 4, beta 1 subunit, also known as AP4B1, is a human gene.^[1]

The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; MIM 607244), a medium chain, mu-4 (AP4M1; MIM 602296), and a small chain, sigma-4 (AP4S1; MIM 607243).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit.

[edit] Further reading

Dell'Angelica EC, Mullins C, Bonifacino JS (1999). "AP-4, a novel protein complex related to clathrin adaptors.". J. Biol. Chem. 274 (11): 7278-85. PMID 10066790.
Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex.". Mol. Biol. Cell 10 (8): 2787-802. PMID 10436028.
Takatsu H, Futatsumori M, Yoshino K, et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.". Biochem. Biophys. Res. Commun. 284 (4): 1083-9. doi:10.1006/bbrc.2001.5081. PMID 11409905.
Cayrol C, Cougoule C, Wright M (2003). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1.". Biochem. Biophys. Res. Commun. 298 (5): 720-30. PMID 12419313.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.