AP1S2

From Wikipedia, the free encyclopedia

Adaptor-related protein complex 1, sigma 2 subunit

Identifiers

AP1S2; DC22; MGC:1902; SIGMA1B

External IDs

Gene ontology
Molecular Function:	• protein transporter activity
Cellular Component:	• Golgi apparatus • trans-Golgi network • plasma membrane • coated pit • AP-type membrane coat adaptor complex • AP-1 adaptor complex • coated vesicle membrane
Biological Process:	• transport • intracellular protein transport • receptor-mediated endocytosis

Orthologs

Human

Mouse

Entrez

8905

n/a

Refseq

NM_003916 (mRNA)
NP_003907 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Adaptor-related protein complex 1, sigma 2 subunit, also known as AP1S2, is a human gene.^[1]

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit.

[edit] Further reading

Kirchhausen T (2000). "Clathrin.". Annu. Rev. Biochem. 69: 699-727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580-5. doi:10.1093/embo-reports/kve141. PMID 11463741.
Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris) 19 (1): 100-6. PMID 12836198.
Kirchhausen T, Davis AC, Frucht S, et al. (1991). "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.". J. Biol. Chem. 266 (17): 11153-7. PMID 2040623.
Takatsu H, Sakurai M, Shin HW, et al. (1998). "Identification and characterization of novel clathrin adaptor-related proteins.". J. Biol. Chem. 273 (38): 24693-700. PMID 9733768.
Craig HM, Pandori MW, Guatelli JC (1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11229-34. PMID 9736718.
Bresnahan PA, Yonemoto W, Ferrell S, et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.". Curr. Biol. 8 (22): 1235-8. PMID 9811606.
Greenberg M, DeTulleo L, Rapoport I, et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4.". Curr. Biol. 8 (22): 1239-42. PMID 9811611.
Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.". J. Virol. 73 (2): 1350-61. PMID 9882340.
Wyss S, Berlioz-Torrent C, Boge M, et al. (2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter].". J. Virol. 75 (6): 2982-92. doi:10.1128/JVI.75.6.2982-2992.2001. PMID 11222723.
Doray B, Ghosh P, Griffith J, et al. (2002). "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.". Science 297 (5587): 1700-3. doi:10.1126/science.1075327. PMID 12215646.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Janvier K, Craig H, Hitchin D, et al. (2003). "HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes.". J. Biol. Chem. 278 (10): 8725-32. doi:10.1074/jbc.M210115200. PMID 12486136.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Coleman SH, Van Damme N, Day JR, et al. (2005). "Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes.". J. Virol. 79 (4): 2066-78. doi:10.1128/JVI.79.4.2066-2078.2005. PMID 15681409.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Coleman SH, Hitchin D, Noviello CM, Guatelli JC (2006). "HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment.". Virology 345 (1): 148-55. doi:10.1016/j.virol.2005.09.045. PMID 16253302.