AP1B1

From Wikipedia, the free encyclopedia

Adaptor-related protein complex 1, beta 1 subunit

PDB rendering based on 1w63.

Available structures: 1w63

Identifiers

Symbol(s)

AP1B1; ADTB1; AP105A; BAM22; CLAPB2

External IDs

OMIM: 600157 MGI: 1096368 HomoloGene: 21972

Gene ontology
Molecular Function:	• transporter activity • binding • protein binding
Cellular Component:	• coated pit • clathrin coat of trans-Golgi network vesicle
Biological Process:	• protein complex assembly • intracellular protein transport • endocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001127 (mRNA)
NP_001118 (protein)

NM_007454 (mRNA)
NP_031480 (protein)

Location

Chr 22: 28.05 - 28.11 Mb

Chr 11: 4.85 - 4.94 Mb

Pubmed search

[1]

[2]

Adaptor-related protein complex 1, beta 1 subunit, also known as AP1B1, is a human gene.^[1]

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.^[1]

[edit] References

^ ^a ^b Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit.

[edit] Further reading

Kirchhausen T (2000). "Clathrin.". Annu. Rev. Biochem. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741.
Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris) 19 (1): 100–6. PMID 12836198.
Peyrard M, Fransson I, Xie YG, et al. (1995). "Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene.". Hum. Mol. Genet. 3 (8): 1393–9. PMID 7987321.
Peyrard M, Pan HQ, Kedra D, et al. (1997). "Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12.". Genomics 36 (1): 112–7. doi:10.1006/geno.1996.0431. PMID 8812422.
Lim DS, Kirsch DG, Canman CE, et al. (1998). "ATM binds to beta-adaptin in cytoplasmic vesicles.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10146–51. PMID 9707615.
Takatsu H, Sakurai M, Shin HW, et al. (1998). "Identification and characterization of novel clathrin adaptor-related proteins.". J. Biol. Chem. 273 (38): 24693–700. PMID 9733768.
Craig HM, Pandori MW, Guatelli JC (1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11229–34. PMID 9736718.
Bresnahan PA, Yonemoto W, Ferrell S, et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.". Curr. Biol. 8 (22): 1235–8. PMID 9811606.
Greenberg M, DeTulleo L, Rapoport I, et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4.". Curr. Biol. 8 (22): 1239–42. PMID 9811611.
Laporte SA, Oakley RH, Zhang J, et al. (1999). "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3712–7. PMID 10097102.
Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells.". Cell 99 (2): 189–98. PMID 10535737.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.
Lai MM, Luo HR, Burnett PE, et al. (2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis.". J. Biol. Chem. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
Nakagawa T, Setou M, Seog D, et al. (2001). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex.". Cell 103 (4): 569–81. PMID 11106728.
Takatsu H, Futatsumori M, Yoshino K, et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID 11409905.
Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly.". Mol. Biol. Cell 12 (7): 1925–35. PMID 11451993.
Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1.". J. Biol. Chem. 277 (24): 21158–66. doi:10.1074/jbc.M112145200. PMID 11912197.