Anxiogenic

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An anxiogenic substance is one that causes anxiety. Anxiogenic effects can be measured by, for example, the hole-board test in rats and mice.[1] A number of agents are used to provoke anxiety (anxiogenes) or panic (panicogenes) in experimental models . Some of the most common substances are: DMCM, sodium lactate, carbon dioxide (CO2), caffeine, yohimbine, serotoninergic agents, mCPP, adrenergic agents and cholecystokinin (CCK) (especially the tetrapeptide and octapeptide fragments CCK-4 and CCK-8) [1]

Anxiolytic substances have the opposite effect: they reduce anxiety.

[edit] References

  1. ^ Takeda, H and Tsuji, M and Matsumiya, T (1998). "Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice". European Journal of Pharmacology 350 (1): 21–29. doi:10.1016/S0014-2999(98)00223-4. 


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