Talk:Antineoplastic

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[edit] modes of action 2 & 3

Modes of action 2 & 3 are unclear: What is exactly inhibited wrt RNA? Is RNA transcription inhibited (likely since there is this big molecule in the way attached to the DNA) or is transcription inhibited?

Is point 3 a result of 1 & 2 or is there another mechanism?

MOAs 2 & 3 are vague and seem to be a direct result of 1. From my lecture notes here it seems that they work via inhibiting topoisomerase II. This also seems to be supported by what's on the anthracycline and doxorubicin pages. I have edited the page to reflect this. Serrin 08:32, 4 August 2006 (UTC)