Anti-p62 antibodies
From Wikipedia, the free encyclopedia
| Autoantibody(s) | |
|---|---|
| Anti-p62 | |
| Autoantigen Isoform |
Nucleoporin 62kDA |
| Autoantigen gene | NUP62 |
| Affected organ(s) | Bile Duct |
| Associated Disease(s) |
Primary biliary cirrhosis |
| HLA associations | DR2 (weak) |
Anti-p62 antibodies (AP62A) are found in a primary biliary cirrhosis.[1] p62 is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.[2][3] The autoantigen is the nucleoporin 62kDA protein.
[edit] References
- ^ Wesierska-Gadek J, Hohenuer H, Hitchman E, Penner E (1996). "Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis". Gastroenterology 110 (3): 840–7. PMID 8608894.
- ^ Miyachi K, Hankins RW, Matsushima H, et al (2003). "Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study". J. Autoimmun. 20 (3): 247–54. PMID 12753810.
- ^ Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J (2005). "Antinuclear antibodies in primary biliary cirrhosis". Semin. Liver Dis. 25 (3): 298–310. doi:. PMID 16143945.
