ANKRD1

From Wikipedia, the free encyclopedia

Ankyrin repeat domain 1 (cardiac muscle)

Identifiers

ANKRD1; CARP; ALRP; C-193; CVARP; MCARP; bA320F15.2

External IDs

OMIM: 609599 MGI: 1097717 HomoloGene: 8289

Gene ontology
Molecular Function:	• DNA binding • transcription corepressor activity
Cellular Component:	• nucleus • transcription factor complex • cytoplasm
Biological Process:	• regulation of transcription from RNA polymerase II promoter • defense response • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014391 (mRNA)
NP_055206 (protein)

NM_013468 (mRNA)
NP_038496 (protein)

Location

Chr 10: 92.66 - 92.67 Mb

Chr 19: 36.18 - 36.18 Mb

Pubmed search

[1]

[2]

Ankyrin repeat domain 1 (cardiac muscle), also known as ANKRD1, is a human gene.^[1]

The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.^[1]

[edit] References

^ ^a ^b Entrez Gene: ANKRD1 ankyrin repeat domain 1 (cardiac muscle).

[edit] Further reading

Chu W, Burns DK, Swerlick RA, Presky DH (1995). "Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells.". J. Biol. Chem. 270 (17): 10236–45. PMID 7730328.
Bang ML, Mudry RE, McElhinny AS, et al. (2001). "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.". J. Cell Biol. 153 (2): 413–27. PMID 11309420.
Zolk O, Frohme M, Maurer A, et al. (2002). "Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure.". Biochem. Biophys. Res. Commun. 293 (5): 1377–82. doi:10.1016/S0006-291X(02)00387-X. PMID 12054667.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
de Waard V, van Achterberg TA, Beauchamp NJ, et al. (2003). "Cardiac ankyrin repeat protein (CARP) expression in human and murine atherosclerotic lesions: activin induces CARP in smooth muscle cells.". Arterioscler. Thromb. Vasc. Biol. 23 (1): 64–8. PMID 12524226.
Nakamura K, Nakada C, Takeuchi K, et al. (2003). "Altered expression of cardiac ankyrin repeat protein and its homologue, ankyrin repeat protein with PEST and proline-rich region, in atrophic muscles in amyotrophic lateral sclerosis.". Pathobiology 70 (4): 197–203. doi:10.1159/000069329. PMID 12679596.
Miller MK, Bang ML, Witt CC, et al. (2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.". J. Mol. Biol. 333 (5): 951–64. PMID 14583192.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Torrado M, Nespereira B, López E, et al. (2005). "ANKRD1 specifically binds CASQ2 in heart extracts and both proteins are co-enriched in piglet cardiac Purkinje cells.". J. Mol. Cell. Cardiol. 38 (2): 353–65. doi:10.1016/j.yjmcc.2004.11.034. PMID 15698842.
Park JH, Liu L, Kim IH, et al. (2005). "Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells.". Cancer Res. 65 (7): 2804–14. doi:10.1158/0008-5472.CAN-04-2221. PMID 15805281.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Witt SH, Labeit D, Granzier H, et al. (2007). "Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling.". J. Muscle Res. Cell. Motil. 26 (6-8): 401–8. doi:10.1007/s10974-005-9022-9. PMID 16450059.
Matsuura K, Uesugi N, Hijiya N, et al. (2007). "Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis.". Hum. Pathol. 38 (3): 410–9. doi:10.1016/j.humpath.2006.09.006. PMID 17239933.