ANKRD15

From Wikipedia, the free encyclopedia


Ankyrin repeat domain 15
Identifiers
Symbol(s) ANKRD15; DKFZp451G231; KANK; KIAA0172; MGC43128
External IDs OMIM: 607704 MGI: 2147707 HomoloGene: 17706
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23189 107351
Ensembl ENSG00000107104 ENSMUSG00000032702
Uniprot Q14678 n/a
Refseq NM_015158 (mRNA)
NP_055973 (protein)		 NM_181404 (mRNA)
NP_852069 (protein)
Location Chr 9: 0.46 - 0.74 Mb Chr 19: 25.47 - 25.5 Mb
Pubmed search [1] [2]

Ankyrin repeat domain 15, also known as ANKRD15, is a human gene.[1]

This gene encodes a protein containing four ankyrin repeat domains in its C-terminus. The suggested role for this protein is in tumorigenesis of renal cell carcinoma. Two alternatively spliced transcript variants encoding different isoforms have been identified.[1]

[edit] References

  1. ^ a b Entrez Gene: ANKRD15 ankyrin repeat domain 15.

[edit] Further reading

  • Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. PMID 8724849. 
  • Sarkar S, Roy BC, Hatano N, et al. (2002). "A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma.". J. Biol. Chem. 277 (39): 36585–91. doi:10.1074/jbc.M204244200. PMID 12133830. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Roy BC, Aoyagi T, Sarkar S, et al. (2005). "Pathological characterization of Kank in renal cell carcinoma.". Exp. Mol. Pathol. 78 (1): 41–8. doi:10.1016/j.yexmp.2004.08.012. PMID 15596059. 
  • Wang Y, Onishi Y, Kakinuma N, et al. (2005). "Alternative splicing of the human Kank gene produces two types of Kank protein.". Biochem. Biophys. Res. Commun. 330 (4): 1247–53. doi:10.1016/j.bbrc.2005.03.106. PMID 15823577. 
  • Wang Y, Kakinuma N, Zhu Y, Kiyama R (2007). "Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin.". J. Cell. Sci. 119 (Pt 19): 4002–10. doi:10.1242/jcs.03169. PMID 16968744. 
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