AMY2A

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Amylase, alpha 2A; pancreatic
PDB rendering based on 1b2y.
Available structures: 1b2y, 1bsi, 1c8q, 1cpu, 1hny, 1jxj, 1jxk, 1kb3, 1kbb, 1kbk, 1kgu, 1kgw, 1kgx, 1mfu, 1mfv, 1nm9, 1q4n, 1smd, 1u2y, 1u30, 1u33, 1xcw, 1xcx, 1xd0, 1xd1, 1xgz, 1xh0, 1xh1, 1xh2, 1xv8, 1z32, 2cpu, 3cpu
Identifiers
Symbol(s) AMY2A; AMY2; AMY2B; PA
External IDs OMIM: 104650 MGI: 88019 HomoloGene: 20179
Orthologs
Human Mouse
Entrez 279 11722
Ensembl n/a ENSMUSG00000074264
Uniprot n/a Q921Y7
Refseq NM_000699 (mRNA)
NP_000690 (protein)		 NM_007446 (mRNA)
NP_031472 (protein)
Location n/a Chr 3: 113.55 - 113.57 Mb
Pubmed search [1] [2]

Amylase, alpha 2A; pancreatic, also known as AMY2A, is a human gene.[1]

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.[1]

[edit] References

  1. ^ a b Entrez Gene: AMY2A amylase, alpha 2A; pancreatic.

[edit] Further reading

  • Kaczmarek MJ, Rosenmund H (1977). "The action of human pancreatic and salivary isoamylases on starch and glycogen.". Clin. Chim. Acta 79 (1): 69-73. PMID 890964. 
  • Jacob M, Lainé J, LeBel D (1993). "Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase.". Biochem. Cell Biol. 70 (10-11): 1105-14. PMID 1284286. 
  • Groot PC, Mager WH, Henriquez NV, et al. (1991). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers.". Genomics 8 (1): 97-105. PMID 2081604. 
  • Nishide T, Nakamura Y, Emi M, et al. (1986). "Primary structure of human salivary alpha-amylase gene.". Gene 41 (2-3): 299-304. PMID 2423416. 
  • Horii A, Emi M, Tomita N, et al. (1988). "Primary structure of human pancreatic alpha-amylase gene: its comparison with human salivary alpha-amylase gene.". Gene 60 (1): 57-64. PMID 2450054. 
  • Gumucio DL, Wiebauer K, Caldwell RM, et al. (1988). "Concerted evolution of human amylase genes.". Mol. Cell. Biol. 8 (3): 1197-205. PMID 2452973. 
  • Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (1988). "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene.". Nucleic Acids Res. 16 (17): 8261-76. PMID 2458567. 
  • Groot PC, Bleeker MJ, Pronk JC, et al. (1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes.". Genomics 5 (1): 29-42. PMID 2788608. 
  • Groot PC, Bleeker MJ, Pronk JC, et al. (1988). "Human pancreatic amylase is encoded by two different genes.". Nucleic Acids Res. 16 (10): 4724. PMID 3260028. 
  • Wise RJ, Karn RC, Larsen SH, et al. (1986). "A complementary DNA sequence that predicts a human pancreatic amylase primary structure consistent with the electrophoretic mobility of the common isozyme, Amy2 A.". Mol. Biol. Med. 2 (5): 307-22. PMID 6336237. 
  • Tricoli JV, Shows TB (1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1.". Somat. Cell Mol. Genet. 10 (2): 205-10. PMID 6608795. 
  • Nishide T, Emi M, Nakamura Y, Matsubara K (1984). "Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected]". Gene 28 (2): 263-70. PMID 6610603. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Qian M, Haser R, Buisson G, et al. (1994). "The active center of a mammalian alpha-amylase. Structure of the complex of a pancreatic alpha-amylase with a carbohydrate inhibitor refined to 2.2-A resolution.". Biochemistry 33 (20): 6284-94. PMID 8193143. 
  • Brayer GD, Luo Y, Withers SG (1996). "The structure of human pancreatic alpha-amylase at 1.8 A resolution and comparisons with related enzymes.". Protein Sci. 4 (9): 1730-42. PMID 8528071. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Rydberg EH, Sidhu G, Vo HC, et al. (1999). "Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris.". Protein Sci. 8 (3): 635-43. PMID 10091666. 
  • Brayer GD, Sidhu G, Maurus R, et al. (2000). "Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.". Biochemistry 39 (16): 4778-91. PMID 10769135. 
  • Aughsteen AA (2001). "A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas.". Saudi medical journal 22 (5): 410-5. PMID 11376382. 
  • Numao S, Maurus R, Sidhu G, et al. (2002). "Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.". Biochemistry 41 (1): 215-25. PMID 11772019. 
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