AMPD2

From Wikipedia, the free encyclopedia

Adenosine monophosphate deaminase 2 (isoform L)

Identifiers

External IDs

OMIM: 102771 MGI: 88016 HomoloGene: 2979

Gene ontology
Molecular Function:	• AMP deaminase activity • hydrolase activity
Cellular Component:	• cellular_component
Biological Process:	• purine nucleotide metabolic process • purine ribonucleoside monophosphate biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004037 (mRNA)
NP_004028 (protein)

NM_028779 (mRNA)
NP_083055 (protein)

Location

Chr 1: 109.96 - 109.98 Mb

Chr 3: 108.2 - 108.21 Mb

Pubmed search

[1]

[2]

Adenosine monophosphate deaminase 2 (isoform L), also known as AMPD2, is a human gene.^[1]

[edit] References

^ Entrez Gene: AMPD2 adenosine monophosphate deaminase 2 (isoform L).

[edit] Further reading

Mahnke-Zizelman DK, Sabina RL (1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons.". J. Biol. Chem. 267 (29): 20866–77. PMID 1400401.
Bausch-Jurken MT, Mahnke-Zizelman DK, Morisaki T, Sabina RL (1992). "Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA.". J. Biol. Chem. 267 (31): 22407–13. PMID 1429593.
Van den Bergh F, Sabina RL (1996). "Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L.". Biochem. J. 312 ( Pt 2): 401–10. PMID 8526848.
Mahnke-Zizelman DK, van den Bergh F, Bausch-Jurken MT, et al. (1996). "Cloning, sequence and characterization of the human AMPD2 gene: evidence for transcriptional regulation by two closely spaced promoters.". Biochim. Biophys. Acta 1308 (2): 122–32. PMID 8764830.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Haas AL, Sabina RL (2003). "N-terminal extensions of the human AMPD2 polypeptide influence ATP regulation of isoform L.". Biochem. Biophys. Res. Commun. 305 (2): 421–7. PMID 12745092.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.