Amorpha-4,11-diene synthase

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In enzymology, an amorpha-4,11-diene synthase (EC 4.2.3.24) is an enzyme that catalyzes the chemical reaction

2-trans,6-trans-farnesyl diphosphate $\rightleftharpoons$ amorpha-4,11-diene + diphosphate

Hence, this enzyme has one substrate, 2-trans,6-trans-farnesyl diphosphate, and two products, amorpha-4,11-diene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming). This enzyme is also called amorphadiene synthase.

[edit] References

IUBMB entry for 4.2.3.24
BRENDA references for 4.2.3.24 (Recommended.)
PubMed references for 4.2.3.24
PubMed Central references for 4.2.3.24
Google Scholar references for 4.2.3.24
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PE (2006). "Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate". Arch. Biochem. Biophys. 448: 150–5. doi:10.1016/j.abb.2005.07.015. PMID 16143293.