AMN (gene)

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Amnionless homolog (mouse)
Identifiers
Symbol(s) AMN; PRO1028
External IDs OMIM: 605799 MGI: 1934943 HomoloGene: 12804
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 81693 93835
Ensembl ENSG00000166126 ENSMUSG00000021278
Uniprot Q9BXJ7 Q99JB7
Refseq NM_030943 (mRNA)
NP_112205 (protein)		 NM_033603 (mRNA)
NP_291081 (protein)
Location Chr 14: 102.46 - 102.47 Mb Chr 12: 111.72 - 111.72 Mb
Pubmed search [1] [2]

Amnionless homolog (mouse), also known as AMN, is a human gene.[1]

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.[1]

[edit] References

  1. ^ a b Entrez Gene: AMN amnionless homolog (mouse).

[edit] Further reading

  • Kozyraki R, Gofflot F (2008). "Multiligand endocytosis and congenital defects: roles of cubilin, megalin and amnionless.". Curr. Pharm. Des. 13 (29): 3038–46. PMID 17979745. 
  • Wang X, Bornslaeger EA, Haub O, et al. (1996). "A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.". Dev. Biol. 177 (1): 274–90. doi:10.1006/dbio.1996.0162. PMID 8660894. 
  • Tomihara-Newberger C, Haub O, Lee HG, et al. (1999). "The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives.". Dev. Biol. 204 (1): 34–54. doi:10.1006/dbio.1998.9034. PMID 9851841. 
  • Dunn NR, Hogan BL (2001). "How does the mouse get its trunk?". Nat. Genet. 27 (4): 351–2. doi:10.1038/86829. PMID 11279507. 
  • Kalantry S, Manning S, Haub O, et al. (2001). "The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain.". Nat. Genet. 27 (4): 412–6. doi:10.1038/86912. PMID 11279523. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tanner SM, Aminoff M, Wright FA, et al. (2003). "Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia.". Nat. Genet. 33 (3): 426–9. doi:10.1038/ng1098. PMID 12590260. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Fyfe JC, Madsen M, Højrup P, et al. (2004). "The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless.". Blood 103 (5): 1573–9. doi:10.1182/blood-2003-08-2852. PMID 14576052. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.". Genomics 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941. 
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