Talk:Amitriptyline

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[edit] Tinnitus

Additionally, there is anecdotal and some research evidence that it reduces the subjective experience of tinnitus

—The preceding unsigned comment was added by 194.201.24.215 (talk • contribs). 19:31, 11 April 2005

I was prescribed this drug for the treatment of shingles. I dont know whether it contributed to my recovery or not.

—Preceding unsigned comment added by 210.55.251.5 (talk • contribs) 23:37, 15 December 2005
No, it is good for postherpetic neuralgia, the pain that often persists after shingles. JFW | T@lk 22:53, 15 December 2005 (UTC)


This drug was prescribed to me to prevent migraine headaches. This is not mentioned. It has done nothing to diminish my tinnitus, however.

—Preceding unsigned comment added by 24.165.187.238 (talk • contribs) 18:08, 6 May 2005


This drug was prescribed for headaches that I have been having for a year and a half. The drug helped and served its purpose, however, the side effects were severe depression and panic attacks. Increased anxiety was also a side effect and the results were less desired than the solution. Good luck with anyone who is on this.

—Preceding unsigned comment added by 207.232.186.50 (talk • contribs) 17:38, 21 July 2006
Given that at higher dosages the drug is used to treat depression and anxiety you were unlucky in having to make sensible decission that you did. But I think as the dosage is increased, most patients would eventually report greater side effects that benefit (usually of dry mouth or drowsiness). The trick in such cases is often to take a dose just below that for maximum headache/migraine/chronic pain control to minimise the side effects and so gain the optimal overall effect (after all 100% stopping of migraines yet side effects rated as 100% unbearable is of no help, vs 90% less migrains and 10% of side effects may be seen by patient as a good compromnise). Still not the ideal drug for everyone and there are other alternatives tried in a similar manner (either less muscarinic acting tricyclics - eg nortriptyline or lofepramine and some of the antiepleptic medicines, eg. valproate, carbamazepine and Gabapentin) David Ruben Talk 00:13, 22 July 2006 (UTC)

[edit] Neuropathic pain

How does this drug treat nerve pain/damage?

[edit] So much missing information.

Information on mechanism of action, contraindications, kinetics, and interactions sorely needed. 72.64.203.15 20:33, 29 June 2007 (UTC)JH

Brand names, or "sold under" names, for various countries would also be useful, if only as search targets. dafydd (talk) 14:29, 3 January 2008 (UTC)

[edit] Temporomandibular Joint Dysfunction

I was prescribed this drug at 10mg doasge to prevent my jaw locking. I don't know how common a practice this is.—Preceding unsigned comment added by 82.46.170.107 (talk • contribs) 15:41, 9 January 2008

Amitriptyline, or from UK Maxillo-facial surgeons more often Nortriptyline, is seen as a normal 1st stage approach to the problem. They act as pain modifiers in what is often a neuralgic type pain (see Temporomandibular joint disorder, although that need citations to verify for this encyclopaedia, this is quite typical and effective UK-at-least practice) David Ruben Talk 15:11, 9 January 2008 (UTC)

Interestingly, I have TMJ and was prescribed 25mg for other reasons, but have found my TMJ and headaches, and neck pain, to be less frequent. I am a 27 year old with fibromyalgia, IBS, chronic pain and fatigue, and am in the blood line of nervous system disorders. Ironically, I was put on this for an alternate solution to my previous anti-depressant, Wellbutrin, which was absolutely not the right medication for me! Since I have been on the Amitriptyline 25 mg/daily I have actually felt like ME again. The first time in years! (The main thing I find is that I require 9-12 hours of sleep per night to function well the next day. Otherwise, I am just exhausted and even a good espresso won't fix that). I suppose it's an oldie but a goodie... and keep in mind that I am normally an advocate for anti-medication treatment. It's a good medication for calming down anxiety sufferers, and slowing down the mind so you can actually get some rest!) - Socally (talk) 08:02, 22 January 2008 (UTC)

Amitriptyline is in deed one of the most reliable antidepressants, sort of a "gold standard", its main drawback being strong anticholinergic and cardiologic side effects; it is, however, one of the most effective drugs for agitated/anxious major depression, for otherwise somaticaly healthy patients, if carefully titrated. By the way, am I the only one who noticed the distinctive odor of amitriptyline? I first thought that it comes from an excipient in the tablet formulation, but after having smell to several brands, I smelled pure amitriptyline hydrochloride and it definitely has a slight, distinctive, styrene-like odor....--84.163.81.116 (talk) 13:57, 12 April 2008 (UTC)

[edit] Explosive Diarrhoea?

hey all, I think 'explosive diarrhoea' listed as the side effects is vandalism, originally written with typo errors that someone eventually corrected. Not 100% sure though. Clinical evidence anyone? Squiggle (talk) 18:46, 22 April 2008 (UTC)