Aminoglycoside N3'-acetyltransferase

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In enzymology, an aminoglycoside N3'-acetyltransferase (EC 2.3.1.81) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + a 2-deoxystreptamine antibiotic CoA + N₃'-acetyl-2-deoxystreptamine antibiotic

Thus, the two substrates of this enzyme are acetyl-CoA and 2-deoxystreptamine antibiotic, whereas its two products are CoA and N3'-acetyl-2-deoxystreptamine antibiotic.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase. Other names in common use include 3'-aminoglycoside acetyltransferase, and 3-N-aminoglycoside acetyltransferase.

[edit] References

• IUBMB entry for 2.3.1.81
• BRENDA references for 2.3.1.81 (Recommended.)
• PubMed references for 2.3.1.81
• PubMed Central references for 2.3.1.81
• Google Scholar references for 2.3.1.81
• Davies J, O'Connor S (1978). "Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin". Antimicrob. Agents. Chemother. 14: 69–72. PMID 356726. 

[edit] External links

The CAS registry number for this enzyme class is 60120-42-5.

• IUBMB entry for 2.3.1.81

• KEGG entry for 2.3.1.81

• BRENDA entry for 2.3.1.81

• NiceZyme view of 2.3.1.81

• EC2PDB: PDB structures for 2.3.1.81

• PRIAM entry for 2.3.1.81

• PUMA2 entry for 2.3.1.81

• IntEnz: Integrated Enzyme entry for 2.3.1.81

• MetaCyc entry for 2.3.1.81

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0046353: aminoglycoside N3'-acetyltransferase

• AMIGO entry for GO code 0046353: aminoglycoside N3'-acetyltransferase