Aminoacyl-tRNA hydrolase

From Wikipedia, the free encyclopedia

In enzymology, an aminoacyl-tRNA hydrolase (EC 3.1.1.29) is an enzyme that catalyzes the chemical reaction

N-Substituted aminoacyl-tRNA + H₂O N-substituted amino acid + tRNA

Thus, the two substrates of this enzyme are N-Substituted aminoacyl-tRNA and H₂O, whereas its two products are N-substituted amino acid and tRNA.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is aminoacyl-tRNA aminoacylhydrolase. Other names in common use include aminoacyl-transfer ribonucleate hydrolase, N-substituted aminoacyl transfer RNA hydrolase, and peptidyl-tRNA hydrolase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1RYB, 1WN2, 1XTY, 2D3K, 2E1B, 2PTH, 2Z2I, 2Z2J, and 2Z2K.

[edit] References

• IUBMB entry for 3.1.1.29
• BRENDA references for 3.1.1.29 (Recommended.)
• PubMed references for 3.1.1.29
• PubMed Central references for 3.1.1.29
• Google Scholar references for 3.1.1.29
• Jost JP, Bock RM (1969). "Enzymatic hydrolysis of N-substituted aminoacyl transfer ribonucleic acid in yeast". J. Biol. Chem. 244: 5866–73. PMID 4981785. 

[edit] External links

The CAS registry number for this enzyme class is 9054-98-2.

• IUBMB entry for 3.1.1.29

• KEGG entry for 3.1.1.29

• BRENDA entry for 3.1.1.29

• NiceZyme view of 3.1.1.29

• EC2PDB: PDB structures for 3.1.1.29

• PRIAM entry for 3.1.1.29

• PUMA2 entry for 3.1.1.29

• IntEnz: Integrated Enzyme entry for 3.1.1.29

• MetaCyc entry for 3.1.1.29

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004045: aminoacyl-tRNA hydrolase

• AMIGO entry for GO code 0004045: aminoacyl-tRNA hydrolase