Amino-acid racemase

From Wikipedia, the free encyclopedia

In enzymology, an amino-acid racemase (EC 5.1.1.10) is an enzyme that catalyzes the chemical reaction

an L-amino acid a D-amino acid

Hence, this enzyme has one substrate, L-amino acid, and one product, D-amino acid.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is amino-acid racemase. This enzyme is also called L-amino acid racemase. This enzyme participates in 4 metabolic pathways: glycine, serine and threonine metabolism, cysteine metabolism, D-glutamine and D-glutamate metabolism, and D-arginine and D-ornithine metabolism. It employs one cofactor, pyridoxal phosphate.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2FKP, 2GGG, 2GGH, 2GGI, and 2GGJ.

[edit] References

• IUBMB entry for 5.1.1.10
• BRENDA references for 5.1.1.10 (Recommended.)
• PubMed references for 5.1.1.10
• PubMed Central references for 5.1.1.10
• Google Scholar references for 5.1.1.10
• Soda K, Osumi T (1969). "Crystalline amino acid racemase with low substrate specificity". Biochem. Biophys. Res. Commun. 35: 363–8. doi:10.1016/0006-291X(69)90507-5. PMID 5788493. 

[edit] External links

The CAS registry number for this enzyme class is 9068-61-5.

• IUBMB entry for 5.1.1.10

• KEGG entry for 5.1.1.10

• BRENDA entry for 5.1.1.10

• NiceZyme view of 5.1.1.10

• EC2PDB: PDB structures for 5.1.1.10

• PRIAM entry for 5.1.1.10

• PUMA2 entry for 5.1.1.10

• IntEnz: Integrated Enzyme entry for 5.1.1.10

• MetaCyc entry for 5.1.1.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047661: amino-acid racemase

• AMIGO entry for GO code 0047661: amino-acid racemase

v • d • e Isomerases: Epimerase and racemases (EC 5.1) Amino-acid racemase Phenylalanine racemase (ATP-hydrolysing) - Serine racemase Other Mandelate racemase - UDP galactose epimerase - Methylmalonyl CoA epimerase