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| Alpha operon ribosome binding site |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
109.2 nucleotides |
| Avg identity: |
69% |
|
The alpha operon ribosome binding site in bacteria is surrounded by this complex pseudoknotted RNA structure. Translation of the mRNA produces 4 ribosomal protein products, one of which (S4) acts as a translational repressor by binding to the nested pseudoknot region. The mechanism of repression is thought to involve a conformational switch in the pseudoknot region and ribosome entrapment.[1]
[edit] References
- ^ Schlax, PJ; Xavier KA, Gluick TC, Draper DE (2001). "Translational repression of the Escherichia coli alpha operon mRNA: importance of an mRNA conformational switch and a ternary entrapment complex". J Biol Chem 276: 38494–38501. doi:10.1074/jbc.M106934200. PMID 11504736.
[edit] External links
