Alpha-tubulin N-acetyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an alpha-tubulin N-acetyltransferase (EC 2.3.1.108) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + [alpha-tubulin]-L-lysine CoA + [alpha-tubulin]-N₆-acetyl-L-lysine

Thus, the two substrates of this enzyme are acetyl-CoA and [[[alpha-tubulin]-L-lysine]], whereas its two products are CoA and [[[alpha-tubulin]-N6-acetyl-L-lysine]].

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:[alpha-tubulin]-L-lysine N6-acetyltransferase. Other names in common use include alpha-tubulin acetylase, TAT, alpha-tubulin acetyltransferase, tubulin N-acetyltransferase, acetyl-CoA:alpha-tubulin-L-lysine N-acetyltransferase, and acetyl-CoA:[alpha-tubulin]-L-lysine 6-N-acetyltransferase.

[edit] References

• IUBMB entry for 2.3.1.108
• BRENDA references for 2.3.1.108 (Recommended.)
• PubMed references for 2.3.1.108
• PubMed Central references for 2.3.1.108
• Google Scholar references for 2.3.1.108
• Greer K, Maruta H, L'Hernault SW, Rosenbaum JL (1985). "Alpha-tubulin acetylase activity in isolated Chlamydomonas flagella". J. Cell. Biol. 101: 2081–4. doi:10.1083/jcb.101.6.2081. PMID 4066751. 

[edit] External links

The CAS registry number for this enzyme class is 99889-90-4.

• IUBMB entry for 2.3.1.108

• KEGG entry for 2.3.1.108

• BRENDA entry for 2.3.1.108

• NiceZyme view of 2.3.1.108

• EC2PDB: PDB structures for 2.3.1.108

• PRIAM entry for 2.3.1.108

• PUMA2 entry for 2.3.1.108

• IntEnz: Integrated Enzyme entry for 2.3.1.108

• MetaCyc entry for 2.3.1.108

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019799: tubulin N-acetyltransferase

• AMIGO entry for GO code 0019799: tubulin N-acetyltransferase