ALOX12

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Arachidonate 12-lipoxygenase

Identifiers

Symbol(s)

ALOX12; 12-LOX; LOG12

External IDs

OMIM: 152391 MGI: 87998 HomoloGene: 560

Gene ontology
Molecular Function:	• arachidonate 12-lipoxygenase activity • iron ion binding • lipoxygenase activity • oxidoreductase activity • potassium channel inhibitor activity • metal ion binding • hepoxilin-epoxide hydrolase activity
Cellular Component:	• cytosol • sarcolemma
Biological Process:	• electron transport • oxygen and reactive oxygen species metabolic process • anti-apoptosis • cell motility • positive regulation of cell proliferation • arachidonic acid metabolic process • leukotriene biosynthetic process • fatty acid oxidation • positive regulation of cell growth • regulation of membrane potential • superoxide release • positive regulation of cell adhesion • negative regulation of cell volume

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000697 (mRNA)
NP_000688 (protein)

NM_007440 (mRNA)
NP_031466 (protein)

Location

Chr 17: 6.84 - 6.86 Mb

Chr 11: 70.06 - 70.07 Mb

Pubmed search

[1]

[2]

Arachidonate 12-lipoxygenase, also known as ALOX12, is a human gene.^[1]

[edit] References

^ Entrez Gene: ALOX12 arachidonate 12-lipoxygenase.

[edit] Further reading

Yoshimoto T, Arakawa T, Hada T, et al. (1992). "Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.". J. Biol. Chem. 267 (34): 24805–9. PMID 1447217.
Funk CD, Funk LB, FitzGerald GA, Samuelsson B (1992). "Characterization of human 12-lipoxygenase genes.". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3962–6. PMID 1570320.
Izumi T, Hoshiko S, Rådmark O, Samuelsson B (1990). "Cloning of the cDNA for human 12-lipoxygenase.". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7477–81. PMID 2217179.
Yoshimoto T, Yamamoto Y, Arakawa T, et al. (1990). "Molecular cloning and expression of human arachidonate 12-lipoxygenase.". Biochem. Biophys. Res. Commun. 172 (3): 1230–5. PMID 2244907.
Funk CD, Furci L, FitzGerald GA (1990). "Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.". Proc. Natl. Acad. Sci. U.S.A. 87 (15): 5638–42. PMID 2377602.
Flatman S, Morgan A, McDonald-Gibson RG, et al. (1988). "12-Lipoxygenase activity in human uterine cervix.". Prostaglandins Leukot. Essent. Fatty Acids 32 (2): 87–94. PMID 3406043.
Wong PY, Westlund P, Hamberg M, et al. (1985). "15-Lipoxygenase in human platelets.". J. Biol. Chem. 260 (16): 9162–5. PMID 3926763.
Nakamura M, Ueda N, Kishimoto K, et al. (1995). "Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells.". J. Histochem. Cytochem. 43 (3): 237–44. PMID 7868854.
Hussain H, Shornick LP, Shannon VR, et al. (1994). "Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis.". Am. J. Physiol. 266 (1 Pt 1): C243–53. PMID 8304420.
Arora JK, Lysz TW, Zelenka PS (1996). "A role for 12(S)-HETE in the response of human lens epithelial cells to epidermal growth factor and insulin.". Invest. Ophthalmol. Vis. Sci. 37 (7): 1411–8. PMID 8641843.
Hagmann W, Gao X, Timar J, et al. (1996). "12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization.". Exp. Cell Res. 228 (2): 197–205. doi:10.1006/excr.1996.0317. PMID 8912711.
Nakamura M, Yamamoto S, Ishimura K (1997). "Subcellular localization of arachidonate 12-lipoxygenase and morphological effect of its overexpression on murine keratinocytes.". Cell Tissue Res. 288 (2): 327–34. PMID 9082968.
Nigam S, Kumar GS, Sutherland M, et al. (1999). "Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma.". Int. J. Cancer 82 (6): 827–31. PMID 10446449.
Tang K, Finley RL, Nie D, Honn KV (2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.". Biochemistry 39 (12): 3185–91. PMID 10727209.
Tornhamre S, Elmqvist A, Lindgren JA (2000). "15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation.". Biochim. Biophys. Acta 1484 (2-3): 298–306. PMID 10760478.
Chen BK, Tsai TY, Huang HS, et al. (2003). "Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene.". J. Biomed. Sci. 9 (2): 156–65. PMID 11914583.
Winer I, Normolle DP, Shureiqi I, et al. (2003). "Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.". Melanoma Res. 12 (5): 429–34. PMID 12394183.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gu J, Wen Y, Mison A, Nadler JL (2003). "12-lipoxygenase pathway increases aldosterone production, 3',5'-cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protein kinase activation in H295R human adrenocortical cells.". Endocrinology 144 (2): 534–43. PMID 12538614.
Fridman C, Ojopi EP, Gregório SP, et al. (2003). "Association of a new polymorphism in ALOX12 gene with bipolar disorder.". European archives of psychiatry and clinical neuroscience 253 (1): 40–3. doi:10.1007/s00406-003-0404-y. PMID 12664313.