Talk:Alkaline phosphatase
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Could someone write a little more on separating the izoenzymes? Thanks. --Eleassar my talk 18:05, 12 September 2005 (UTC)
-- Could we mention that AlkPhos might be raised in polymalgia rheumatica? -- —Preceding unsigned comment added by 129.215.37.83 (talk) 12:42, 9 November 2007 (UTC)
- Seconded. I just added something from the Oxford Textbook about heat stability, but I reckon there are now more sensitive ELISA or nephelometry-based modalities available. JFW | T@lk 19:50, 12 September 2005 (UTC)
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[edit] Figure
Will someone cite this figure? Also, it should have a PDB number.
[edit] Use in research
The change form 14:07, 9 December 2005 says - "Removing these phosphates prevents the DNA from ligating (the 5' end attaching to the 3' end of another molecule), thereby preventing DNA degradation until the next step of the process for which it is being prepared". Isn't an intramolecular ligation posible too? I think so, well, depending on how long these molecules are, right? If that's correct then we should revert this part to the original. Plz post a comment. Boris 13:57, 15 December 2005 (UTC)
[edit] Human: Diagnostic Use
It would be helpful if the article could indicate what level would be considered significantly elevated.
[edit] Levels of Alkaline Phosphatase
My Alkaline phosphatase is extremely high. Who could tell me why that is, and how our body recieves Alkaline phosphatase (i.e. what kind of food contains Alkaline phosphatase). How could I make it lower..Please help
- ALP is a generally considered a marker of high bone activity - it is secreted by osteoblasts (bone forming cells). High ALP is often high in a high bone turnover state - i.e. when bone resorption is also high. This can be confirmed by other biochemical markers of bone resorption.
- ALP is high in conditions such as Paget's disease of bone - a high bone turnover state that can lead to weakened and deformed bones, as well as bone pain.
- These conditions are treated with drugs, such as bisphosphonates rather than diet. I suggest you consult your GP if you are concerned. Dr Aaron 04:40, 1 August 2006 (UTC)
I think the "normal" alkaline phosphatase levels should be adjusted or at least a disclaimer should be put that "normal" depends on the lab performing the test. Robbins/Goljan pathology go with 45-150 U/L as the normal range. As it is in the Wiki page, it's way too low as a "normal" range. Plus, it doesn't compensate for the fact that children have higher levels than adults. —Preceding unsigned comment added by Dirtyvu (talk • contribs) 05:03, 26 March 2008 (UTC)
