Alkylacetylglycerophosphatase

From Wikipedia, the free encyclopedia

In enzymology, an alkylacetylglycerophosphatase (EC 3.1.3.59) is an enzyme that catalyzes the chemical reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphate + H₂O 1-alkyl-2-acetyl-sn-glycerol + phosphate

Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3-phosphate and H₂O, whereas its two products are 1-alkyl-2-acetyl-sn-glycerol and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase. Other names in common use include 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase, and alkylacetylglycerophosphate phosphatase. This enzyme participates in ether lipid metabolism.

[edit] References

• IUBMB entry for 3.1.3.59
• BRENDA references for 3.1.3.59 (Recommended.)
• PubMed references for 3.1.3.59
• PubMed Central references for 3.1.3.59
• Google Scholar references for 3.1.3.59
• Lee TC, Malone B, Snyder F (1986). "A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen". J. Biol. Chem. 261: 5373–7. PMID 3007498. 

[edit] External links

The CAS registry number for this enzyme class is 102925-45-1.

• IUBMB entry for 3.1.3.59

• KEGG entry for 3.1.3.59

• BRENDA entry for 3.1.3.59

• NiceZyme view of 3.1.3.59

• EC2PDB: PDB structures for 3.1.3.59

• PRIAM entry for 3.1.3.59

• PUMA2 entry for 3.1.3.59

• IntEnz: Integrated Enzyme entry for 3.1.3.59

• MetaCyc entry for 3.1.3.59

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047647: alkylacetylglycerophosphatase

• AMIGO entry for GO code 0047647: alkylacetylglycerophosphatase